From Detection to Cure – Emerging Roles for Urinary Tumor DNA (utDNA) in Bladder Cancer

Purpose of review This review sought to define the emerging roles of urinary tumor DNA (utDNA) for diagnosis, monitoring, and treatment of bladder cancer. Building from early landmark studies the focus is on recent studies, highlighting how utDNA could aid personalized care. Recent findings Recent r...

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Published inCurrent oncology reports Vol. 26; no. 8; pp. 945 - 958
Main Authors Linscott, Joshua A., Miyagi, Hiroko, Murthy, Prithvi B., Yao, Sijie, Grass, G. Daniel, Vosoughi, Aram, Xu, Hongzhi, Wang, Xuefeng, Yu, Xiaoqing, Yu, Alice, Zemp, Logan, Gilbert, Scott M., Poch, Michael A., Sexton, Wade J., Spiess, Philippe E., Li, Roger
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2024
Springer Nature B.V
Subjects
Biomarkers
Biopsy
Bladder cancer
Cell cycle
Clinical trials
Cytology
Disease management
DNA methylation
Epigenetics
Genomes
Medicine
Medicine & Public Health
Oncology
Plasma
Research centers
Review
Topical Collection on Genitourinary Cancers
Tumors
Urine
Urothelial cancer
Precision oncology
Cell-free DNA
Liquid biopsy
Urinary biomarkers
Bladder cancer
Urinary tumor DNA
Circulating tumor DNA
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Summary:Purpose of review This review sought to define the emerging roles of urinary tumor DNA (utDNA) for diagnosis, monitoring, and treatment of bladder cancer. Building from early landmark studies the focus is on recent studies, highlighting how utDNA could aid personalized care. Recent findings Recent research underscores the potential for utDNA to be the premiere biomarker in bladder cancer due to the constant interface between urine and tumor. Many studies find utDNA to be more informative than other biomarkers in bladder cancer, especially in early stages of disease. Points of emphasis include superior sensitivity over traditional urine cytology, broad genomic and epigenetic insights, and the potential for non-invasive, real-time analysis of tumor biology. Summary utDNA shows promise for improving all phases of bladder cancer care, paving the way for personalized treatment strategies. Building from current research, future comprehensive clinical trials will validate utDNA's clinical utility, potentially revolutionizing bladder cancer management.
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ISSN:1523-3790
1534-6269
1534-6269
DOI:10.1007/s11912-024-01555-0