Biological Response of Chinese Hamster B14-150 Cells to Sequential Combined Exposure to Protons and 12C Ions

Proton and ion radiation therapy, when used both as single radiation and in mixed radiation mode, have a number of advantages over the conventional γ-therapy that are determined by physical characteristics of accelerated particles. The paper presents the results of an in vitro study of the effective...

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Published inBulletin of experimental biology and medicine Vol. 176; no. 1; pp. 38 - 41
Main Authors Troshina, M. V., Koryakina, E. V., Potetnya, V. I., Solov’ev, A. N., Saburov, V. O., Lychagin, A. A., Ivanov, S. A., Kaprin, A. D., Koryakin, S. N.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.11.2023
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cells
Dependence
Efficiency
Internal Medicine
Laboratory Medicine
Medical research
Pathology
Physical characteristics
Protons
Radiation therapy
Tumor cells
combined exposure
C ions
protons
tumor cells
cells survival
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Summary:Proton and ion radiation therapy, when used both as single radiation and in mixed radiation mode, have a number of advantages over the conventional γ-therapy that are determined by physical characteristics of accelerated particles. The paper presents the results of an in vitro study of the effectiveness of sequential exposures of Chinese hamster tumor cells B14-150 to proton (p) and 12 C ion beams. We used 4 irradiation schemes differing by the sequence of exposure and the contribution of each radiation to the total dose. Synergism was shown for 12 C ions dose contribution of 45% (taking into account the coefficient of relative biological efficiency) and the sequence 12 C→p.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05963-3