Disruption of estrogen receptor beta in mice brain results in pathological alterations resembling Alzheimer disease

• Published in: Acta pharmacologica Sinica Vol. 25; no. 4; pp. 452 - 457
• Main Authors: Zhang, Qing-hong, Huang, Yan-hong, Hu, Yu-zhen, Wei, Gemg-ze, Han, Xue-feng, Lu, Shun-yan, Zhao, Yu-feng
• Format: Journal Article
• Language: English
• Published: United States 01.04.2004
• Subjects: Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Amygdala - metabolism; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - metabolism; Animals; Apolipoproteins E - metabolism; Brain - pathology; Cerebral Cortex - metabolism; Estrogen Receptor beta; Female; Hippocampus - metabolism; Mice; Mice, Inbred C57BL; Plaque, Amyloid - pathology; Receptors, Estrogen - metabolism; 免疫组织化学; 动物实验; 病理形态学; 载脂蛋白E; 阿海默滋病; 雌激素受体β
• ISSN: 1671-4083; 1745-7254

AIM: To study the pathological characteristics of the mice with estrogen receptor β (ERβ) disruption in brain.METHODS: Immunohistochemistry method was applied in the study. RESULTS: β-Amyloid peptide(Aβ42) and apolipoprotein E (ApoE) immunoreactive substances were accumulated notably in cortex and limbic structures such as the hippocampus and amygdala in brain, resembling the pathological changes of human Alzheimer disease(AD). Aβ formed cloudy-like deposits in parenchyma of brain, while apoE also deposited along or surrounding the blood vessels. CONCLUSIONS: ERβ is crucial to the development of neural degenerative disease, so modulation of Aβ metabolism via ERβ signal pathway might be beneficial for AD prevention or therapy.