OBESITY IS AN UNAVOIDABLE ADVERSE DRUG REACTION TO ATYPICAL ANTIPSYCHOTICS

• Published in: Journal of evolution of medical and dental sciences Vol. 4; no. 22; pp. 3865 - 3872
• Main Authors: Verma, Hemlata, Rao, S.S, Verma, V.K
• Format: Journal Article
• Language: English
• Published: Akshantala Enterprises Private Limited 16.03.2015
• Subjects: Complications and side effects; Drug therapy; Drugs; Innovations; Medical research; Mentally ill persons; Obesity; Olanzapine; Patient compliance; Risk factors; Risperidone; Schizophrenia
• ISSN: 2278-4748; 2278-4802
• DOI: 10.14260/jemds/2015/556

Atypical antipsychotics are an important advance in the treatment of schizophrenia and other psychiatric illness, and have become widely used as first-line pharmacotherapy for psychosis. This study is a longitudinal prospective observational study of ADRs of Atypical Antipsychotic drugs in patients of psychiatric illness. Information of ADRs was data based and collected from OPD. The noted ADRs were assessed by using Naranjo's probability assessment scale, and WHO (UMC) causality assessment scale. Majority of patients in this study belonged to 21-30 years age group which was 24% of the total. According to the severity of ADRs, majority of cases were reported of having weight gain 38.46% followed by sedation 19.23%, dry mouth 13.46% and orthostatic hypotension 5.76%. 88.47% were reported as type A and 11.53% were reported as type B. Definite (certain) relationship was established in 30. 40% patients while probable in 57.62% and 11.53% ADRs were categorized as possible. The ADRs can be prevented by collecting reliable information about their frequencies and possible risk factors. KEYWORDS: Atypical antipsychotics, ADRs, Olanzapine, Risperidone, Obesity.