Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes
Abstract The association of polymorphisms affecting lipid metabolism with the risk of myocardial infarction (MI) in type 2 diabetes mellitus was investigated. The Genetics, Outcomes and Lipids in type 2 Diabetes (GOLD) Study is a prospective, multicenter study, conducted on 990 patients presenting d...
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Published in | Atherosclerosis Vol. 204; no. 1; pp. 165 - 170 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ireland Ltd
01.05.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Abstract The association of polymorphisms affecting lipid metabolism with the risk of myocardial infarction (MI) in type 2 diabetes mellitus was investigated. The Genetics, Outcomes and Lipids in type 2 Diabetes (GOLD) Study is a prospective, multicenter study, conducted on 990 patients presenting diabetes and MI ( n = 386), or diabetes without previous manifestation of stroke, peripheral or coronary arterial disease ( n = 604), recruited from 27 institutions in Brazil. APO A1 (A/G −75 and C/T +83) and APO C3 (C/G 3’UTR) non-coding sequences, CETP (Taq 1B), LPL (D9N), APO E (ε2, ε3, ε4,), PON-1 (Q192R), and two LCAT variants Arg147 → Trp and Tyr171 → Stop were tested by PCR-RFLP. There was a higher prevalence of LPL DN genotype (19% vs.12%, p = 0.03) and a higher frequency of the N allele (11% vs. 7%) among subjects with MI when compared to controls, with an odds ratio of MI for carriers of 9N allele of 2.46 (95% CI = 1.79–3.39, p < 0.0001). This association was present in men and women, in non-smokers and in hypertensive patients. A logistic regression model including gender, duration of diabetes, systolic blood pressure, HDL-C, left ventricle hypertrophy and D9N polymorphism showed that the latter still remained significantly associated with MI (OR = 1.50, 95% CI = 1.02–2.25, p = 0.049). These findings suggest that D9N polymorphism can be a useful risk marker for myocardial infarction and that further potential candidate genes should be screened for exploratory analysis and for future therapeutic intervention in diabetes. |
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ISSN: | 0021-9150 1879-1484 |
DOI: | 10.1016/j.atherosclerosis.2008.08.006 |