Changes in Controlled-release Functions of Pulverized Low-substituted Hydroxypropylcellulose by Wet Granulation

Pulverized L-HPC (low-substituted hydroxypropylcellulose, LH41) is used as a controlled-release matrix filler, depending on the amount of loading in its formulation. The flowability and packability of the L-HPC particles in drugs were facilitated by wet granulation to improve their availabilities fo...

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Bibliographic Details
Published inFuntai Kogakkaishi Vol. 29; no. 6; pp. 456 - 459
Main Authors KAWASHIMA, Yoshiaki, TAKEUCHI, Hirofumi, HINO, Tomoaki, NIWA, Toshiyuki, LIN, Tzu-Lang, SEKIGAWA, Fujio, KAWAHARA, Keiko
Format Journal Article
LanguageEnglish
Published The Society of Powder Technology, Japan 1992
Subjects
Controlled-release Matrix Base
Flowability
Low-substituted Hydroxypropylcellulose
Swelling Force
Wet Granulation
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Summary:Pulverized L-HPC (low-substituted hydroxypropylcellulose, LH41) is used as a controlled-release matrix filler, depending on the amount of loading in its formulation. The flowability and packability of the L-HPC particles in drugs were facilitated by wet granulation to improve their availabilities for practical uses. Controlled-release functions of the L-HPC were reserved through granulation with ethanol, whereas they were lost during granulation with water. The differences in the controlled release functions of agglomerated L-HPC were explained in terms of their swelling properties, depending on the type of slovent used for the granulation.
ISSN:0386-6157
1883-7239
DOI:10.4164/sptj.29.456