Chemical and Chemoenzymatic Syntheses of Bacillithiol: A Unique Low-Molecular-Weight Thiol amongst Low G + C Gram-Positive Bacteria

Das volle Programm: Der kürzlich entdeckte Thiol‐Cofaktor Bacillithiol (BSH), seine Biosynthesevorstufe und sein symmetrisches Disulfid wurden auf zwei Arten hergestellt. Das Fosfomycinresistenzprotein (FosB) zeigt BSH‐S‐Transferaseaktivität mit einer starken Bevorzugung von BSH gegenüber L‐Cystein...

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Published inAngewandte Chemie Vol. 123; no. 31; pp. 7239 - 7242
Main Authors Sharma, Sunil V., Jothivasan, Vishnu K., Newton, Gerald L., Upton, Heather, Wakabayashi, Judy I., Kane, Melissa G., Roberts, Alexandra A., Rawat, Mamta, La Clair, James J., Hamilton, Chris J.
Format Journal Article
LanguageEnglish
German
Published Weinheim WILEY-VCH Verlag 25.07.2011
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Bacteria
Chemistry
Firmicute
Fosfomycin
Naturstoffe
Thiol-s-Transferase
Totalsynthesen
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Summary:Das volle Programm: Der kürzlich entdeckte Thiol‐Cofaktor Bacillithiol (BSH), seine Biosynthesevorstufe und sein symmetrisches Disulfid wurden auf zwei Arten hergestellt. Das Fosfomycinresistenzprotein (FosB) zeigt BSH‐S‐Transferaseaktivität mit einer starken Bevorzugung von BSH gegenüber L‐Cystein als Thiolsubstrat.
Bibliography:istex:13BDBD7C40F5538C89009EF4F210E1C914FF22A2
National Institutes of Health - No. AI-72133
Engineering and Physical Sciences Research Council (EPSRC)
We acknowledge financial support from the BBSRC Grant BB/H013504/1, the Overseas Research Studentship Awards Scheme, the University of East Anglia, the National Institutes of Health Grant AI-72133, and the Engineering and Physical Sciences Research Council (EPSRC). We also thank the Mass Spectrometry Service Centre, Swansea and Dr. Su at UC San Diego for their invaluable assistance.
BBSRC - No. BB/H013504/1
ArticleID:ANGE201100196
ark:/67375/WNG-LCR1GRWV-L
We acknowledge financial support from the BBSRC Grant BB/H013504/1, the Overseas Research Studentship Awards Scheme, the University of East Anglia, the National Institutes of Health Grant AI‐72133, and the Engineering and Physical Sciences Research Council (EPSRC). We also thank the Mass Spectrometry Service Centre, Swansea and Dr. Su at UC San Diego for their invaluable assistance.
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201100196