Procedure for red blood cell labelling with 99mTc-HMPAO. Methodology and quality control
We present here results on the labelling of red blood cells with 99mTc-HMPAO as an alternative method to the usual in vitro technique. Anticoagulant agents, the labelling medium with plasma, and the lapse of time between 99mTc-HMPAO preparation and labelling are the main factors which affect the eff...
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Published in | Nuclear medicine and biology Vol. 21; no. 7; pp. 963 - 967 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Inc
01.10.1994
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | We present here results on the labelling of red blood cells with
99mTc-HMPAO as an alternative method to the usual
in vitro technique. Anticoagulant agents, the labelling medium with plasma, and the lapse of time between
99mTc-HMPAO preparation and labelling are the main factors which affect the efficiency of the procedure. A 93.9 ± 2.3% labelling yield was obtained with freshly prepared
99mTc-HMPAO.
In vitro (tracer elution of 4.3 ± 1.2% at 60 mins) and
in vivo (percentage of plasma activity at 60 mins, 7.8 ± 2.8%) stability of the label, as well as image quality, qualify
99mTc-HMPAO labelled red blood cells as a suitable agent for clinical use. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0969-8051 1872-9614 |
DOI: | 10.1016/0969-8051(94)90086-8 |