HEPATOPROTECTIVE AND GASTRO PROTECTIVE STUDIES OF Terminalia arjuna LEAVES EXTRACT AND PHYTOCHEMICAL PROFILE

• Published in: Banat's Journal of Biotechnology Vol. 5; no. 10; pp. 30 - 36
• Main Authors: Said, Ataa, El-Fishawy, Ahlam M, El-Shenawy, Siham, Hawas, Usama W, Aboelmagd, Mohamed
• Format: Journal Article
• Language: English
• Published: Timisoara Banat's University of Agricultural Sciences and Veterinary Medicine Timisoara 01.07.2014
• Subjects: Terminalia arjuna
• ISSN: 2068-4673; 2068-4738
• DOI: 10.7904/2068-4738-V(10)-30

The methanol extract of T. arjuna leaves was evaluated as hepatoprotective and gastroprotective against Swiss albino rats. In hepatoprotective study, the liver damage induced by paracetamol while the gastric lesion induced by absolute ethanol in the gastro protective study. The extract was given orally (250 mg/kg,500 mg/kg and 1,000 mg/kg) in different experimental models in both studies. The extract at dose (500 mg/kg) showed significant reduction in ALT serum level by 19.9% while at dose (1,000 mg/kg) it reduced significantly serum ALT, AST and ALP levels by -26.15%, -25.46% and -23.69%, respectively as compared with paracetamol treated group. In the gastro protective study, the extract produced significant reduction in the number and severity of mucosal lesion by (-52.1% & -67.3%, -66.7% & -71.2 % and -68.8% & -77.6%), respectively.