Effects of streptozotocin-induced type 1 diabetes mellitus on protein and ion concentrations in ocular tissues of the rat
This study investigated the effects of streptozotocin (STZ)-induced diabetes mellitus (DM) on protein and cation levels in ocular tissues (lenses, cornea, lacrimal glands and retina with sclera) of rats. Diabetic rats and their lacrimal glands weighed significantly less (p < 0.05) than age-matche...
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Published in | Dubai diabetes and endocrinology journal Vol. 13; no. 3; pp. 154 - 158 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Basel, Switzerland
01.03.2019
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Subjects | |
Online Access | Get full text |
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Summary: | This study investigated the effects of streptozotocin (STZ)-induced diabetes mellitus (DM) on protein and cation levels in
ocular tissues (lenses, cornea, lacrimal glands and retina with sclera) of rats. Diabetic rats and their lacrimal glands weighed
significantly less (p < 0.05) than age-matched controls. Diabetic animals also had significantly (p < 0.05) elevated blood
glucose and significantly reduced (p < 0.05) plasma insulin compared to controls. Total protein concentrations in the cornea,
lens, lacrimal gland and retina with sclera were markedly reduced compared to controls (circa 50%-90%). Diabetic cornea,
lenses, lacrimal glands, and retina with sclera contained more Ca2+ (p < 0.05) than age-matched controls (2-3 fold). Levels of
Zn2+ were also elevated (p < 0.05) in the cornea and retina with sclera of diabetic rats, as compared to control rats (2-3 fold),
but were unaffected in lenses and lacrimal glands. In contrast, levels of Cu2+, Mg2+, Na+ and K+ were significantly reduced (p
< 0.05) in all ocular tissues of diabetic rats when compared to control animals (circa 30%-70%). These results show that
STZ-induced DM is generally associated with significant physiochemical changes in ocular tissues of rats with changes
observed in body weight, blood glucose, and insulin levels and protein and cation concentrations compared to healthy agematched
controls. Based on these data, it has been speculated that diabetes may induce changes in ocular tissues that include:
higher protein turnover through increased protease activity and changes in Na+ / K+ channel function. It is suggested that
these changes may be associated with diabetic retinopathy, diabetic cornea and sight impairment. (Int J Diabetes Metab
13:154-158, 2005) |
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ISSN: | 2673-1797 1606-7754 2673-1738 2073-5944 |
DOI: | 10.1159/000497584 |