Clinical utility of cerebrospinal fluid-placental alkaline phosphatase for the diagnosis of intracranial germinoma

The clinical utility of measuring cerebrospinal fluid placental alkaline phosphatase (CSF-PLAP) was evaluated in three patients with germinoma. CSF-PLAP was elevated in two patients with suprasellar germinoma who were symptomatic before developing typical radiological findings. The third patient, wh...

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Published inPediatric hematology oncology journal Vol. 7; no. 4; pp. 173 - 176
Main Authors Obu, Satoshi, Umeda, Katsutsugu, Iwanaga, Kougoro, Saida, Satoshi, Kato, Itaru, Hiramatsu, Hidefumi, Mineharu, Yohei, Arakawa, Yoshiki, Uto, Megumi, Mizowaki, Takashi, Adachi, Souichi, Daifu, Tomoo, Kawai, Masahiko, Takita, Junko
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2022
Elsevier
Subjects
Diagnosis
Germinoma
Intracranial germ cell tumor
Placental alkaline phosphatase
Tumor marker
GH
DI
MRI
ICE
AFP
HCG
CARE
PLAP
Intracranial germ cell tumor
Tumor marker
Placental alkaline phosphatase
APHD
Germinoma
CSF
GCT
Diagnosis
Gd
CEA
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Summary:The clinical utility of measuring cerebrospinal fluid placental alkaline phosphatase (CSF-PLAP) was evaluated in three patients with germinoma. CSF-PLAP was elevated in two patients with suprasellar germinoma who were symptomatic before developing typical radiological findings. The third patient, who had been radiologically diagnosed with a pineal mature teratoma, was suspected of having a germinoma component due to elevated CSF-PLAP; this patient received adjuvant radiochemotherapy. The presence of a germinoma-specific tumor marker may aid in the early diagnosis of suspicious cases at initial clinical presentation and in the accurate subtype classification of intracranial germ cell tumors.
ISSN:2468-1245
2468-1245
DOI:10.1016/j.phoj.2022.10.252