Preparation of 99Mo/99mTc generator based on alumina 99Mo-molybdate (VI) gel

• Published in: Journal of radioanalytical and nuclear chemistry Vol. 299; no. 3; pp. 1859 - 1864
• Main Authors: El-Absy, M. A., El-Amir, M. A., Fasih, T. W., Ramadan, H. E., El-Shahat, M. F.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.03.2014
• Subjects: Aluminum base alloys; Aluminum oxide; Chemistry; Chemistry and Materials Science; Chromatography; Diagnostic Radiology; Dissolution; Foils; Generators; Hadrons; Heavy Ions; Inorganic Chemistry; Nanostructure; Nuclear Chemistry; Nuclear Physics; Physical Chemistry; Saline solutions; Mo gel; Mo; Al; Tc generator; Quality control
• ISSN: 0236-5731; 1588-2780
• DOI: 10.1007/s10967-014-2930-7

In this work alumina 99 Mo-molybdate (VI) gel is evaluated as a column matrix for use in the preparation of small chromatographic column type 99m Tc generator. Alumina molybdate (VI) gel is prepared by dissolving inactive MoO 3 with aluminum foil in 5 M NaOH solution containing 99 Mo radiotracer. After complete dissolution, 0.5 H 2 O 2 was added to the reaction mixture solution and acidified to pH 5.5 with concentrated HNO 3 . The formed AlMo precipitate was washed with NaNO 3 solution, dried at 50 °C for 24 h and then packed in the form of a chromatographic column for elution of the generated 99m Tc radionuclide with physiological saline solution (0.9 % NaCl). Greater than 86 % of the generated 99m Tc activity is immediately and reproducibly eluted with passing 10 mL of the saline solution through 2.0 g of alumina 99 Mo-molybdate column bed at a flow rate of about 1.0 mL/min. The high radiochemical ≥98.6 % TcO 4 − , radionuclidic ≥99.90 % 99m Tc and chemical purities of the eluates satisfy the specifications for use in nuclear medicine.