Development of spinal bone metastasis by MBT-2 tumor in mice

The biology of skeletal metastasis is poorly understood. In order to establish an animal model of spinal bone metastasis, we injected MBT-2 tumor cells into the tail vein of C3H/He mice while the inferior vena cava was occluded. By this technique, the tumor cells were transferred into the vertebral...

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Bibliographic Details
Published inNippon Hinyokika Gakkai zasshi Vol. 85; no. 11; p. 1636
Main Authors Nishijima, Y, Koiso, K, Nemoto, R
Format Journal Article
LanguageJapanese
Published Japan 20.11.1994
Subjects
Animals
Disease Models, Animal
Female
Mice
Mice, Inbred C3H
Neoplastic Cells, Circulating - pathology
Spinal Neoplasms - pathology
Spinal Neoplasms - secondary
Tumor Cells, Cultured
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Summary:The biology of skeletal metastasis is poorly understood. In order to establish an animal model of spinal bone metastasis, we injected MBT-2 tumor cells into the tail vein of C3H/He mice while the inferior vena cava was occluded. By this technique, the tumor cells were transferred into the vertebral plexus. Spinal lesions developed in 12 of 15 (80%) experimental mice and in none of the control mice. All bone lesions resulted in local bone destruction. The predominant site of bone metastasis was lumbarvertebrae; other affected sites were thrpelvis and coccyges. This model should be of value in understanding the pathogenesis of spinal bone metastasis and in studying the effects of various agents on the prevention and control of spinal lesions.
ISSN:0021-5287
DOI:10.5980/jpnjurol1989.85.1636