INTRAVENOUS VAGAL NERVE STIMULATION IN ACUTE MYOCARDIAL INFARCTION (AMI) MARKEDLY IMPROVES CARDIAC FUNCTION AND PREVENTS CHRONIC HEART FAILURE

At one month after I/R, iVNS strikingly decreased the infarct size more than 80% (Figure), lowered LVEDP (4.4±3.0 vs. 15.8±7.6 mmHg, p<0.05), and increased end-systolic elastance (Ees, sonomicrometric volumetry) (15.4±5.9 vs. 7.4±3.4 mmHg/ml, p<0.05) as well as LV ejection fraction (echocardio...

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Published inJournal of the American College of Cardiology Vol. 65; no. 10; p. A797
Main Authors Arimura, Takahiro, Saku, Keita, Kakino, Takamori, Akashi, Takuya, Nishikawa, Takuya, Murayama, Yoshinori, Takehara, Takako, Toyama, Takeshi, Ide, Tomomi, Kishi, Takuya, Sunagawa, Kenji, Medicine, Department of Cardiovascular
Format Journal Article
LanguageEnglish
Published New York Elsevier Inc 17.03.2015
Elsevier Limited
Subjects
Cardiology
Cardiovascular
Heart attacks
Internal Medicine
Long term
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Summary:At one month after I/R, iVNS strikingly decreased the infarct size more than 80% (Figure), lowered LVEDP (4.4±3.0 vs. 15.8±7.6 mmHg, p<0.05), and increased end-systolic elastance (Ees, sonomicrometric volumetry) (15.4±5.9 vs. 7.4±3.4 mmHg/ml, p<0.05) as well as LV ejection fraction (echocardiography) (60.8±3.1 vs. 48.6±6.5 %, p<0.05), suggesting that iVNS preserved LV systolic function.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(15)60797-5