Safety of chemotherapy of MDR/XDR-TB patients in high HIV prevalence settings

The review used 61 literature sources to discuss 13 publications devoted to safety of treatment of HIV-associated drug-resistant tuberculosis using basic and new regimens of chemotherapy. According to the literature, no additive toxic effects were detected during treatment with anti-tuberculosis and...

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Bibliographic Details
Published inTuberkulëz i bolezni lëgkikh Vol. 100; no. 11; pp. 56 - 65
Main Authors Kukurika, A. V., Veselova, E. I., Parolina, L. E., Lovacheva, O. V.
Format Journal Article
LanguageEnglish
Russian
Published New Terra Publishing House 09.12.2022
Subjects
антиретровирусная терапия
безопасность
вич
млу/шлу-тб
нежелательные побочные реакции
противотуберкулезные препараты
схемы лечения
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Summary:The review used 61 literature sources to discuss 13 publications devoted to safety of treatment of HIV-associated drug-resistant tuberculosis using basic and new regimens of chemotherapy. According to the literature, no additive toxic effects were detected during treatment with anti-tuberculosis and antiretroviral drugs. According to the literature data, no additive toxic effect was found during treatment with anti-tuberculosis and antiretroviral drugs. In conditions of high prevalence of HIV, the pharmacovigilance of drug interactions in combination therapy is particularly relevant since HIV can indirectly increase the number of ADRs not only due to cross-toxicity but also severe immunosuppression, development of immune system recovery syndrome, opportunistic infections, a characteristic intoxication syndrome, a low index body weight and individual characteristics of patients in this category.
ISSN:2075-1230
2542-1506
DOI:10.21292/2075-1230-2022-100-11-56-65