Antibiofilm Activity of Fukoidans Isolated from Brown Algae

• Published in: Антибиотики и Химиотерапия Vol. 68; no. 9-10; pp. 5 - 11
• Main Authors: E. V. Matosova, N. N. Besednova, M. I. Kusaikin, B. G. Andryukov, I. D. Makarenkova, M. Yu. Shchelkanov, I. N. Lyapun, M. P. Bynina, S. P. Ermakova, T. N. Zvyagintseva
• Format: Journal Article
• Language: Russian
• Published: LLC "Publishing House OKI" 15.01.2024
• Subjects: biofilms, yersinia pseudotuberculosis, inhibition, fucoidans (sulfated polysaccharides), brown algae
• ISSN: 0235-2990
• DOI: 10.37489/0235-2990-2023-68-9-10-5-11

Biofilms play a significant role in the existence of bacteria under adverse conditions and the pathogenesis of infections. They contribute to the creation of reservoirs of antibiotic-resistant pathogens. This determines the relevance of the search for biologically active substances that inhibit the formation of biofilms. In recent years, the objects of intensive study are fucoidans — sulfated polysaccharides from marine brown algae, which have a wide polyfunctional spectrum of action. Their influence on the formation of Yersinia pseudotuberculosis biofilm in a dynamic model simulating the natural conditions of ecosystems of fucoidans belonging to different structural groups was investigated in this study. They are synthesized by brown algae: Fucus evanescens, Saccharina cichorioides, and Saccharina japonica. The fucoidan isolated from F.evanescens have showed the most pronounced antibiotic activity. The authors developed a new approach that allows obtaining stable results of multidirectional action of sulfated polysaccharides on the biofilm formation of Y.pseudotuberculosis.