Effect of vitamin D and interferon α-2b on cytokine profile in pregnant women with vaginal infections

A study was conducted to evaluate effectiveness of vitamin D and interferon α-2b preparations on cytokine profile in pregnant women with vaginal infections. It was shown that pregnant women with vs. without bacterial vaginosis were featured with low vitamin D level in 53.8–60.5% cases. Administratio...

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Published inInfekt͡s︡ii͡a︡ i immunitet Vol. 10; no. 3; pp. 524 - 532
Main Authors Kostinov, M. P., Ignatieva, M. A., Novikova, S. V., Shmitko, A. D., Polischuk, V. B., Akhmatova, N. K., Savisko, A. A., Kostinov, A. M.
Format Journal Article
LanguageEnglish
Published Sankt-Peterburg : NIIÈM imeni Pastera 01.08.2020
Subjects
cytokines
interferons
pregnant women
vaginal infections
vitamin d
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Summary:A study was conducted to evaluate effectiveness of vitamin D and interferon α-2b preparations on cytokine profile in pregnant women with vaginal infections. It was shown that pregnant women with vs. without bacterial vaginosis were featured with low vitamin D level in 53.8–60.5% cases. Administration of vitamin D and interferon α-2b preparations in combination with antibacterial therapy in pregnant women with bacterial vaginosis conferred anti-inflammatory effect resulting in normalized IL-8 level corresponding to that one in healthy subjects. Use of vitamin D altered interferon status and augmented antimicrobial activity in pregnant women confirmed by reduced rate of ARI episodes.
ISSN:2220-7619
2313-7398
DOI:10.15789/10.15789/2220-7619-EOV-1140