Synthesis of 2-Substituted Benzo[b]furans/furo-Pyridines Catalyzed by NiCl2

The first Ni-catalyzed tandem synthesis of 2-substituted benzo[b]furans/furo-pyridines from 2-halophenols and 1-alkynes was explored under Cu-free and phosphine-free conditions. The protocol was carried out with NiCl2/5-nitro-1, 10-phenanthroline in DMA (N,N-dimethylacetamide) at 120 °C. It was foun...

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Bibliographic Details
Published inCatalysts Vol. 9; no. 12; p. 1019
Main Authors Zhou, Rong, Ding, Yanli, Yang, Mili
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 03.12.2019
Subjects
Alkynes
Catalysis
Catalysts
Chemical reactions
Chemical synthesis
Chromatography
Conflicts of interest
Dimethyl acetamide
Furans
Ligands
Nickel chloride
NMR
Nuclear magnetic resonance
Optimization
Phosphines
Pyridines
Substitutes
Substrates
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Summary:The first Ni-catalyzed tandem synthesis of 2-substituted benzo[b]furans/furo-pyridines from 2-halophenols and 1-alkynes was explored under Cu-free and phosphine-free conditions. The protocol was carried out with NiCl2/5-nitro-1, 10-phenanthroline in DMA (N,N-dimethylacetamide) at 120 °C. It was found to be simple, cost effective, and have a wide substrate scope. Additionally, the method is compatible with heteroaryl substrates, resulting in the formation of 2-substituted benzo[b]furans/furo-pyridines in reasonable to good yields.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal9121019