Palladium(0)-catalyzed direct C–H hetero-arylation of 2-arylimidazo [1,2-a]pyridines with (E)-1-(5-bromothiophen-2-yl)-3-arylprop-2-en-1-ones and their anticancer activity

An efficient palladium(0)-catalyzed direct hetero-arylation of imidazo[1,2- a ]pyridines at the C-3 position of the imidazole ring has been described. All the synthesized compounds 3a–3r were evaluated for their anticancer activity against a panel of four human cancer cell lines and among all the co...

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Published inRSC advances Vol. 5; no. 97; pp. 80057 - 80062
Main Authors Vellakkaran, Mari, Lingayya, Rajaka, Naveen Kumar, Bejjanki, Nagaiah, Kommu, Poornachandra, Y., Ganesh Kumar, C.
Format Journal Article
LanguageEnglish
Published 01.01.2015
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Summary:An efficient palladium(0)-catalyzed direct hetero-arylation of imidazo[1,2- a ]pyridines at the C-3 position of the imidazole ring has been described. All the synthesized compounds 3a–3r were evaluated for their anticancer activity against a panel of four human cancer cell lines and among all the compounds, 3d , 3j , 3k , 3p and 3r showed promising activity at <10 μM.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA15078G