A CLINICAL STUDY ON CARDIOVASCULAR MANIFESTATIONS SECONDARY TO CIRRHOSIS OF LIVER

• Published in: Journal of evolution of medical and dental sciences Vol. 7; no. 3; pp. 264 - 268
• Main Authors: Arvind, M.N, Patel, Shilpa, Balraj K.P
• Format: Journal Article
• Language: English
• Published: Akshantala Enterprises Private Limited 15.01.2018
• Subjects: Analysis; Cardiovascular diseases; Liver cirrhosis; Prevalence studies (Epidemiology)
• ISSN: 2278-4748; 2278-4802
• DOI: 10.14260/jemds/2018/59

BACKGROUND Cirrhosis of liver is a hyperdynamic condition, in which there may be subtle cardiac dysfunction. The aim of this study is to determine the occurrence of cardiovascular changes among patients with cirrhosis of liver, irrespective of aetiology and its association with QTc variation. MATERIALS AND METHODS This study was a case control study. 30 patients with cirrhosis of liver and 30 controls matched for age and sex were subjected to clinical examination followed by ECG and 2D echo to screen for cardiac abnormalities. QTc interval, E/A ratio and LV mass were calculated. RESULTS M: F ratio was 4: 1 with the mean age of 51.5 yrs. 73.3% of the cases were alcoholics. Mean QTc prolongation was 473 ms and significant QTc prolongation was 73% of CPC. Mean LV mass was 186 g and 78.5% of patients in CP-C had elevated LV mass. The mean E/A ratio was 0.85 and 53.3% of patients with E/A ratio [less than or equal to] 1 and mean EF of 55% with 1/3rd of the patients with EF < 50%. No significant change was noted in the control group with respect to QTc, LV mass and E/A ratio. CONCLUSION QTc prolongation, LV mass and E/A ratio assessment in cirrhotics along with Child-Pugh grade can be used to determine the severity of the underlying cardiac abnormality and predict the prognosis of the patient. KEYWORDS CP--Child-Pugh, Cirrhosis of Liver, Cardiac Abnormalities, E/A Ratio, LV Mass.