Recurrent agranulocytosis induced by two different antithyroid agents

A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil. When the thyrotoxicosis recurred, accompanied by a severe psychotic reaction, administration of antithyroid medication was recommenced. The patient was given methimazole instead of propylthiourac...

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Bibliographic Details
Published inMedical journal of Australia Vol. 2; no. 1; p. 38
Main Authors Chen, B, Lang, R, Jutrin, Y, Ravid, M
Format Journal Article
LanguageEnglish
Published Australia 09.07.1983
Subjects
Agranulocytosis - chemically induced
Female
Humans
Hyperthyroidism - drug therapy
Methimazole - adverse effects
Middle Aged
Propylthiouracil - adverse effects
Recurrence
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Summary:A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil. When the thyrotoxicosis recurred, accompanied by a severe psychotic reaction, administration of antithyroid medication was recommenced. The patient was given methimazole instead of propylthiouracil but, 10 weeks later, agranulocytosis again occurred. This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient.
ISSN:0025-729X
DOI:10.5694/j.1326-5377.1983.tb142086.x