Sporulaminals A and B: a pair of unusual epimeric spiroaminal derivatives from a marine-derived fungus Paraconiothyrium sporulosum YK-03

Sporulaminals A ( 1 ) and B ( 2 ), a pair of unusual epimeric spiroaminal derivatives, bearing a 6/4/5/5 tetracyclic ring system derived from bergamotane sesquiterpenoid, were isolated from a marine-derived fungus Paraconiothyrium sporulosum YK-03. Their structures including the absolute configurati...

Full description

Saved in:
Bibliographic Details
Published inRSC advances Vol. 6; no. 48; pp. 42361 - 42366
Main Authors Zhang, Li-Hua, Feng, Bao-Min, Chen, Gang, Li, Sheng-Ge, Sun, Yi, Wu, Hong-Hua, Bai, Jiao, Hua, Hui-Ming, Wang, Hai-Feng, Pei, Yue-Hu
Format Journal Article
LanguageEnglish
Published 2016
Online AccessGet full text

Cover

More Information
Summary:Sporulaminals A ( 1 ) and B ( 2 ), a pair of unusual epimeric spiroaminal derivatives, bearing a 6/4/5/5 tetracyclic ring system derived from bergamotane sesquiterpenoid, were isolated from a marine-derived fungus Paraconiothyrium sporulosum YK-03. Their structures including the absolute configurations were elucidated by extensive NMR experiments, crystal X-ray diffraction and computational electronic circular dichroism (ECD) method. Furthermore, the epimerization induced by pH, temperature and H 2 O was revealed, together with the hypothetical biosynthetic pathway.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA01401A