EARLY RESULTS OF FUNCTIONAL AND ANATOMIC ORGAN PRESERVATION IN STAGE I AND STAGE II LARYNGEAL CANCER USING PURE ACCELERATED RADIOTHERAPY

• Published in: Journal of evolution of medical and dental sciences Vol. 6; no. 6; pp. 442 - 447
• Main Authors: Rathithilagam, N, Anandhi, P
• Format: Journal Article
• Language: English
• Published: Akshantala Enterprises Private Limited 19.01.2017
• Subjects: Care and treatment; Health aspects; Laryngeal cancer; Patient outcomes; Quality of life; Radiotherapy
• ISSN: 2278-4748; 2278-4802
• DOI: 10.14260/jemds/2017/97

BACKGROUND Laryngeal cancer is a malignancy associated with significant psychosocial consequence as impairment of Laryngeal function from disease and its treatment results in gross disturbances in breathing, speech and swallowing with profound impact on the patient's lifestyle and self-esteem. MATERIALS AND METHODS Aim of this study is to assess the Local response in early Laryngeal cancer using pure accelerated radiotherapy and to determine the acute toxicity rates. The inclusion criteria, exclusion criteria, pre-treatment workup, treatment protocol, dose calculation, toxicity reporting was done. The study conducted between November 2015 and October 2016 in our Institute. RESULTS Between November 2015 and October 2016, thirty patients met with the eligibility criteria for the protocol and were recruited. The fractionation regimen was according to protocol specification in all patients. The duration of therapy was 39 days in 26 patients and 40 days in 4 patients. With respect to the histology and differentiation, all the 30 patients were found to have squamous cell carcinoma with Grade I histology constituting 73.3% and Grade II histology constituting 26.4%. No patients had progressive disease. All the 30 patients were men. Patients were assessed weekly with indirect laryngoscopy and haematological parameters on every Friday; 26 men achieved complete response at the end of treatment course; 16 out of 26 men of the above category achieved complete response at 66 Gy; 10 patients showed complete response 4 weeks after treatment. The other 4 patients showed complete response at the end of 6 weeks. All these 4 patients had stage II cancer, of which 2 had supraglottic cancer and 2 had glottic cancer. CONCLUSION In conclusion, this rather Small Single-Institutional Study showed promising results and acceptable toxicities in patients with early stages of laryngeal cancer. The present schedule is tolerated and can be safely used on an outpatient basis and even in old patients and patients with controlled comorbidities. KEYWORDS Laryngeal Cancer, Treatment, Toxicity, Pure Accelerated Radiotherapy.