Onsite-effects of dual-hemisphere versus conventional single-hemisphere transcranial direct current stimulation A functional MRI study

• Published in: Neural regeneration research Vol. 7; no. 24; pp. 1889 - 1894
• Main Authors: Kwon, Yong Hyun, Jang, Sung Ho
• Format: Journal Article
• Language: English
• Published: India Medknow Publications & Media Pvt. Ltd 25.08.2012; Department of Physical Therapy, Yeungnam College of Science & Technology, Daegu 705-703, Republic of Korea%Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu 705-717, Republic of Korea
• Subjects: Brain; Electrodes; Magnetic resonance imaging; Medical imaging; Neurons; Studies; 传统; 功能性磁共振成像; 功能磁共振成像; 半球; 强度估计; 电刺激; 电流刺激; 直流; functional MRI; neural regeneration; regeneration; primary sensorimotor cortex; dual-hemispheric stimulation; cortical activation; transcranial direct current stimulation; neuroimaging
• ISSN: 1673-5374; 1876-7958
• DOI: 10.3969/j.issn.1673-5374.2012.24.007

We performed functional MRI examinations in six right-handed healthy subjects.During functional MRI scanning,transcranial direct current stimulation was delivered with the anode over the right primary sensorimotor cortex and the cathode over the left primary sensorimotor cortex using dual-hemispheric transcranial direct current stimulation.This was compared to a cathode over the left supraorbital area using conventional single-hemispheric transcranial direct current stimulation. Voxel counts and blood oxygenation level-dependent signal intensities in the right primary sensorimotor cortex regions were estimated and compared between the two transcranial direct current stimulation conditions.Our results showed that dual-hemispheric transcranial direct current stimulation induced greater cortical activities than single-hemispheric transcranial direct current stimulation.These findings suggest that dual-hemispheric transcranial direct current stimulation may provide more effective cortical stimulation than single-hemispheric transcranial direct current stimulation.