Highly enantioselective alkynylation of aldehydes catalyzed by a readily available chiral amino alcohol-based ligand

A new inexpensive chiral amino alcohol-based ligand, (1S,2S)-2-N, N-dimethylamino-1-(p-nitrophenyl)-3-(t-butyldimethylsilyloxy) propane-1-ol, was developed for the asymmetric alkynylation of aliphatic and aromatic aldehydes, to prepare the corresponding propargylic alcohols in high yields with up to...

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Published inChemical communications (Cambridge, England) no. 14; pp. 1524 - 1525
Main Authors Jiang, B, Chen, ZL, Xiong, WN
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 21.07.2002
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
CARBONYL-COMPOUNDS
REAGENTS
KETONE
PROPARGYLIC ALCOHOLS
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Summary:A new inexpensive chiral amino alcohol-based ligand, (1S,2S)-2-N, N-dimethylamino-1-(p-nitrophenyl)-3-(t-butyldimethylsilyloxy) propane-1-ol, was developed for the asymmetric alkynylation of aliphatic and aromatic aldehydes, to prepare the corresponding propargylic alcohols in high yields with up to 99% ee.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/b203984b