Rapid onset vasodilation during baroreceptor loading and unloading

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 325; no. 5; pp. R568 - R575
• Main Authors: Leach, Olivia K., Gifford, Jayson R., Mack, Gary W.
• Format: Journal Article
• Language: English
• Published: 01.11.2023
• ISSN: 0363-6119; 1522-1490; 1522-1490
• DOI: 10.1152/ajpregu.00116.2023

Rapid onset vasodilation (ROV) was linearly related to the peak force of each single 1-s muscle contraction. In addition, ROV is reduced by baroreceptor unloading (LBNP: −10, −120, and −40 mmHg) and increased by baroreceptor loading (LBPP: +10 and +20 mmHg). Without accounting for peak force and the level of baroreceptor engagement makes comparison of ROV in subjects of differing muscle size or strength untenable. The purpose of these experiments was to determine if the increase in vascular conductance following a single muscle contraction (50% of maximal voluntary contraction) (6 male and 6 female subjects) was altered during baroceptor loading and unloading. Rapid onset vasodilation (ROV) was determined by measuring brachial artery blood flow (Doppler ultrasound) and blood pressure (Finapress monitor). Brachial artery vascular conductance was calculated by dividing blood flow by mean arterial pressure. ROV was described by the area under the Δvascular conductance (VC)-time curve during the 30 s following muscle contraction. ROV was determined using chamber pressures of +20, +10, 0, −10, −20, and −40 mmHg (lower body positive and negative pressure, LBPP, and LBNP). We tested the hypothesis that the impact of baroreceptor loading and unloading produces a proportion change in ROV. The level of ROV following each contraction was proportional to the peak force ( r 2 = 0.393, P = 0.0001). Peak force was therefore used as a covariate in further analysis. ROV during application of −40 mmHg LBNP (0.345 ± 0.229 mL·mmHg −1 ) was lower than that observed at Control (0.532 ± 0.284 mL·mmHg −1 , P = 0.034) and +20 mmHg LBPP (0.658 ± 0.364 mL·mmHg −1 , P = 0.0008). ROV was linearly related to chamber pressure from –40 to +20 mmHg chamber pressure ( r 2 = 0.512, P = 0.022, n = 69) and from −20 to +10 mmHg chamber pressure ( r 2 = 0.973, P < 0.0425, n = 45), Overall, vasoconstrictor tone altered with physiologically relevant baroreceptor loading and unloading resulted in a proportion change in ROV. NEW & NOTEWORTHY Rapid onset vasodilation (ROV) was linearly related to the peak force of each single 1-s muscle contraction. In addition, ROV is reduced by baroreceptor unloading (LBNP: −10, −120, and −40 mmHg) and increased by baroreceptor loading (LBPP: +10 and +20 mmHg). Without accounting for peak force and the level of baroreceptor engagement makes comparison of ROV in subjects of differing muscle size or strength untenable.