Efficient method for the synthesis of bisaminoethanethiols and their pyrrole conjugates

By following the protection and deprotection approach, an efficient method for the preparation of bisaminoethanethiol ligands (N2S2) is discussed. In our attempts to synthesize certain nonpeptide analogs of neurotensin, moldel studies were performed by using these ligands for preparing the correspon...

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Bibliographic Details
Published inHeterocycles Vol. 51; no. 12; pp. 2849 - 2854
Main Authors Li, GL, Ma, QG, Ma, B, Grossman, ZD, Pandey, RK
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 01.12.1999
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:By following the protection and deprotection approach, an efficient method for the preparation of bisaminoethanethiol ligands (N2S2) is discussed. In our attempts to synthesize certain nonpeptide analogs of neurotensin, moldel studies were performed by using these ligands for preparing the corresponding pyrrole based conjugates. This methodology provides an alternate approach for developing various target specific agents that cross the blood brain barrier.
ISSN:0385-5414
DOI:10.3987/com-99-8636