99Tcm-HMPAO brain SPET in patients with pseudotumour cerebri

• Published in: Nuclear medicine communications Vol. 17; no. 8; p. 696
• Main Authors: Bakar, M, Tamgac, F, Alper, E, Zarifoglu, M, Bora, I, Turan, F, Ogul, E
• Format: Journal Article
• Language: English
• Published: England 01.08.1996
• Subjects: Adolescent; Adult; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Organotechnetium Compounds; Oximes; Pseudotumor Cerebri - diagnosis; Pseudotumor Cerebri - diagnostic imaging; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon - methods; Tomography, X-Ray Computed
• ISSN: 0143-3636
• DOI: 10.1097/00006231-199608000-00009

The aim of this study was to look for regional cerebral blood flow (rCBF) abnormalities in patients with a recent diagnosis of pseudotumour cerebri (PTC) and to compare 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) cerebral single photon emission tomographic (SPET) findings with those of X-ray computed tomography (CT) and magnetic resonance imaging (MRI). Seventeen consecutive patients aged 14-50 years (mean = 29 years) without previous drug treatment for PTC underwent 99Tcm-HMPAO SPET, cranial CT and MRI studies. No patient had evidence of intracranial mass lesions on the CT or MRI scans. Qualitative analysis of the 99Tcm-HMPAO SPET studies revealed impaired rCBF in nine (53%) patients. The CT and MRI studies revealed an empty sella in two patients, dural sinus thrombosis in one and a slit ventricle in another. Eight of the 13 patients with normal CT and MRI results had rCBF abnormalities. In contrast, three patients with CT and MRI abnormalities had a normal 99Tcm-HMPAO scan. Our results suggest that patients with PTC have functional abnormalities that are revealed by 99Tcm-HMPAO brain SPET.