P28: Determinants of Arterial Stiffness as Marker of Early Vascular Aging in Physicians Population

• Published in: Artery research Vol. 20; no. 1; p. 101
• Main Authors: Shavarova, Elena, Kazahmedov, Eldar, Orlov, Artemiy, Kobalava, Zhanna
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2017; Springer Nature B.V; BMC
• Subjects: ARTERY 17 Poster Presentation abstracts; Body mass index
• ISSN: 1872-9312; 1876-4401; 1876-4401
• DOI: 10.1016/j.artres.2017.10.168

Objective To analyze determinants of arterial stiffness in physician’s population. Methods Observational multicenter study of doctor’s vascular health conducted in 12 Russian cities (VICTORIA study). Demographics; smoking status; anamnesis of arterial hypertension (AH) with/without therapy, medications, established CV, renal diseases, diabetes mellitus; cholesterol and glucose level were registered. Arterial stiffness and vascular age was assessed using BPLab® device with Vasotens® technology (Petr Telegin Company, Nizhny Novgorod, Russia). Arterial stiffness was defined as an elevation of pulse pressure (PP) > 60 mmHg, PWV > 10m/s. Results 464 individuals were included (247 normotensives (mean age 44 yrs) and 237 with AH (mean age 58 yrs)). Mean PP was 46.0 ± 9.8 mm Hg in normotensive group and 58.6 ± 17.4 mm Hg in group with AH (p< 0.001). Mean PWVao was 10.9 ± 2.0m/s and 12.5 ± 2.5m/s in groups without and with AH, respectively (p<0.001). PP>60mm Hg had 11% subjects without AH and 43% with elevated blood pressure (BP) (p < 0.001). PWVao >10m/s had 68% of normotensive subjects and 92% of hypertensive patients (p< 0.001). PWVao correlated with brachial systolic (r = 0,42, p<0.05) and diastolic BP (r = 0,38; p<0.05), central systolic (r = 0,45, p<0.05) and diastolic BP (r = 0,41; p<0.05), age (r = 0,37, p<0.05), heart rate (r = 0,41, p<0.05). There was association between elevated PWVao and body mass index (r = 0,39, p<0.05). In a multiple linear regression model, independent determinants of PWV were systolic BP (β = 0,29, p < 0.001), body mass index (β = 0,19, p< 0.001). Conclusions High PWVao measured by BPLab® device with Vasotens® technology is characterized physician’s population with and without AH. The main determinants of PWVao are systolic BP and body mass index.