Aptamer Functionalized ZnO Thin-Film Transistor Based Multiplexed Detection of Pb and E. Coli in Water

In this work, we demonstrate the multiplexed detection platform to sense lead (Pb2+) and Escherichia coli in water using zinc oxide (ZnO) thin-film transistors (TFTs). Low-voltage ZnO TFTs fabricated by physical vapor deposition were functionalized with (3-Aminopropyl)triethoxysilane (APTES)–glutara...

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Bibliographic Details
Published inIEEE sensors journal Vol. 22; no. 21; pp. 21209 - 21217
Main Authors Honnali, Sanath Kumar, Srinivasa Raghavan, Vikram, Ashwath, Roopa, Saravanavel, Ganapathy, Gunasekhar, K. R., Sambandan, Sanjiv, Gorthi, Sai Siva, O'Driscoll, Benjamin, Jenkins, David
Format Journal Article
LanguageEnglish
Published New York The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 01.11.2022
Subjects
Aminopropyltriethoxysilane
E coli
Electric potential
Integrated circuits
Multiplexing
Physical vapor deposition
Semiconductor devices
Sensor arrays
Target detection
Thin film transistors
Transconductance
Voltage
Zinc oxide
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Summary:In this work, we demonstrate the multiplexed detection platform to sense lead (Pb2+) and Escherichia coli in water using zinc oxide (ZnO) thin-film transistors (TFTs). Low-voltage ZnO TFTs fabricated by physical vapor deposition were functionalized with (3-Aminopropyl)triethoxysilane (APTES)–glutaraldehyde (GLU) molecules. TFTs with such functionalized ZnO surfaces showed good sensitivity and high specificity to the targets with a detection limit of 27 nM and [Formula Omitted] colony forming unit per mL (cfu/mL) for Pb2+ and E. coli, respectively, with the TFT flat-band voltage ([Formula Omitted]) and, hence, the TFT transconductance, being dependent on the target concentration. The direct integration of the sensing with the TFT and associated integrated circuits promises high-density sensor arrays.
ISSN:1530-437X
1558-1748
DOI:10.1109/JSEN.2022.3207467