125 years of virology and ascent of biotechnologies based on viral expressio

The study of viruses lasts for more than a century since their discovery in 1892. In recent decades, viruses are also being actively exploited as a biotechnological tool. Plant-virus-driven transient expression of heterologous proteins is an actively developing production platform; it is the basis o...

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Bibliographic Details
Published inCytology and genetics Vol. 51; no. 2; pp. 87 - 102
Main Authors Giritch, A., Klimyuk, V., Gleba, Y.
Format Journal Article
LanguageEnglish
Published New York Allerton Press 01.03.2017
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Biotechnology industry
Human Genetics
Plant viruses
Proteins
Vectors (Biology)
plant virology
plant-made recombinant proteins
transient expression
plant biotechnology
magnifection
viral vectors
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Summary:The study of viruses lasts for more than a century since their discovery in 1892. In recent decades, viruses are also being actively exploited as a biotechnological tool. Plant-virus-driven transient expression of heterologous proteins is an actively developing production platform; it is the basis of several industrial processes that are currently being used for the production of multiple recombinant proteins. Viral vectors have also become useful tools for research. Viral vectors delivered by Agrobacterium (magnifection) provide for high protein yield, rapid scale up and fast manufacturing. In this review, we explore modern approaches for biotechnological production of recombinant proteins in plants using viral vectors.
ISSN:0095-4527
1934-9440
DOI:10.3103/S0095452717020037