Effects of Electroacupuncture plus dopamine D1 receptor antagonist on somatosensory evoked potentials and behavioral changes in rats with cerebral ischemia-reperfusion

• Published in: Journal of acupuncture and tuina science Vol. 10; no. 3; pp. 133 - 137
• Main Authors: Liu, Cheng-yong, Xu, Ming-shu, Ge, Lin-bao
• Format: Journal Article
• Language: English
• Published: Heidelberg Shanghai Research Institute of Acupuncture and Meridian 01.06.2012; Springer Nature B.V
• Subjects: Acupuncture; Dopamine; Electroacupuncture; Ischemia; Medicine; Medicine & Public Health; Special Topic for 973 Program; Brain Ischemia; 脑缺血; Electroacupuncture; 诱发电位, 躯体感觉; Reperfusion Injury; Rats; 再灌注损伤; R2-03; Acupuncture Therapy; Evoked Potentials, Somatosensory; 大鼠; 针刺疗法; Dopamine Antagonists; 电针; 多巴胺抑制剂
• ISSN: 1672-3597; 1993-0399
• DOI: 10.1007/s11726-012-0589-6

Objective To explore the effects of electroacupuncture (EA) plus dopamine D1 receptor (D1R) antagonist on somatosensory evoked potentials (SEP) and behavioral changes in rats with cerebral ischemia-reperfusion. Methods Forty rats were randomly divided into a normal group, a model group, an EA group, a D1R antagonist group and an EA+D1R antagonist group, with 8 rats in each group. Ischemia-reperfusion model was established in the other 4 groups except the normal group, and they were treated by different ways after modeling successfully. SEP, neural function defect score (NFDS) and beam walking tests were performed before and after modeling, before sacrifice respectively. Results SEP of the EA group, D1R antagonist group and EA+D1R antagonist group showed significant differences when compared with that of the model group ( P <0.05) after treatment. Before treatment, behavioral tests of the model group showed significant decreases compared with those of the normal group ( P <0.05). After treatment, behavioral tests in the EA group, the D1R antagonist group and the EA+D1R antagonist group improved obviously and showed statistical differences compared with those in the model group ( P <0.05). Conclusion EA and D1R antagonist treatments could both promote the neural functional recovery after ischemia-reperfusion and play a brain-protective role, but there was no synergistic effect of EA and D1R antagonist in combination.