P8.14 Elastic Modulus of Human Aortas as a Measure of Stiffness

• Published in: Artery research Vol. 12; no. 1; p. 37
• Main Authors: Connolly, Kathleen, Khir, Ashraf, Li, Ye, Yasmin, Yasmin, Wilkinson, Ian
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2015; Springer Nature B.V; BMC
• Subjects: ARTERY 2015: Poster presentation abstracts
• ISSN: 1872-9312; 1876-4401; 1876-4401
• DOI: 10.1016/j.artres.2015.10.336

Objective To check of relation between blood pressure (BP) and arterial stiffness parameters and measures of left atrial volume to verify whether it is the arterial stiffness-related BP parameters or mean arterial pressure (MAP)that could be responsible for increase in risk of atrial fibrillation. Methods Group of Cracow suburban area inhabitants (n = 205, 66% women) was examined for: 24h(SBP24h, DBP24h, MAP24h, PP24h), central(cSBP, cDBP, cMAP, cPP) BPs, carotid-femoral pulse wave velocity (PWV), parameters of left ventricular mass (LVM, LVMI) and left atrial volume (LAV, LAVI). Anthropometric and clinical data were gathered via questionnaire. With division according to sex-stratified dichotomised LVMI (97g/m2 for women, 110g/m2 for men), correlation analysis was performed and further linear regression models were fitted to identify and assess respective value of steady and pulsatile BP components as factors related to left atrial volume measures. Results After subdivision of population, statistically significant correlations (p < 0,05) were identified only in persons below group-median value of LVMI. For LAV:SBP24h(r = 0,26), MAP24h(r = 0,16), PP24h(r = 0,28), cSBP(r = 0,33), cDBP(r = 0,29), cMAP(r = 0,34), cPP(r = 0,2), PWV(r = 0,25). For LAV-I:SBP24h(r = 0,24), PP24h(r = 0,28), cSBP(r = 0,34), cDBP(r = 0,30), cMAP(r = 0,32), cPP(r = 0,25), PWV(r = 0,28). In regression analysis, only MAP from 24h and pulse wave analysis, relates to left atrial volume, in persons below LVMI group-median value (p< 0,05). For LAV: cMAP(β = 0,35), MAP24h(β = 0,35). For LAVI:cMAP(β = 0,13). In persons with increase in LVMI no relation between BP and PWV and left atrial volume was found. Conclusions Mean arterial pressure is associated with greater left atrial volumes. The fact that relation is blunted in persons with greater LVMI, itself related more to MAP, shows importance of this particular form of target organ damage in relation to LAV.