l-Proline catalyzed facile and efficient synthesis of functionalized indol-3-yl pyran derivatives by multi-component reactions

A simple and green synthetic method for preparation of functionalized indol-3-yl pyran derivatives was developed. The reactions were carried out by one-pot three-component synthesis of 3-cyanoacetyl indoles, malononitrile/cyanoacetate and various aldehydes/isatins/acenaphthenequinone in the presence...

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Bibliographic Details
Published inResearch on chemical intermediates Vol. 43; no. 8; pp. 4575 - 4583
Main Authors Wang, Jing, Liu, Hongzhi, Wen, Ren, Zhu, Zexin, Li, Jie, Zhu, Songlei
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.08.2017
Springer Nature B.V
Subjects
Aldehydes
Catalysis
Chemical synthesis
Chemistry
Chemistry and Materials Science
Derivatives
Indoles
Inorganic Chemistry
Malononitrile
Physical Chemistry
Proline
Proline catalyst
Multi-component reactions
Indol-3-yl pyran
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Summary:A simple and green synthetic method for preparation of functionalized indol-3-yl pyran derivatives was developed. The reactions were carried out by one-pot three-component synthesis of 3-cyanoacetyl indoles, malononitrile/cyanoacetate and various aldehydes/isatins/acenaphthenequinone in the presence of catalytic amount of l -proline. The advantages of this method included straightforward processing, excellent yields, broad substrate scope and environmental friendliness.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-017-2897-4