l-Proline catalyzed facile and efficient synthesis of functionalized indol-3-yl pyran derivatives by multi-component reactions
A simple and green synthetic method for preparation of functionalized indol-3-yl pyran derivatives was developed. The reactions were carried out by one-pot three-component synthesis of 3-cyanoacetyl indoles, malononitrile/cyanoacetate and various aldehydes/isatins/acenaphthenequinone in the presence...
Saved in:
Published in | Research on chemical intermediates Vol. 43; no. 8; pp. 4575 - 4583 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Dordrecht
Springer Netherlands
01.08.2017
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | A simple and green synthetic method for preparation of functionalized indol-3-yl pyran derivatives was developed. The reactions were carried out by one-pot three-component synthesis of 3-cyanoacetyl indoles, malononitrile/cyanoacetate and various aldehydes/isatins/acenaphthenequinone in the presence of catalytic amount of
l
-proline. The advantages of this method included straightforward processing, excellent yields, broad substrate scope and environmental friendliness. |
---|---|
ISSN: | 0922-6168 1568-5675 |
DOI: | 10.1007/s11164-017-2897-4 |