The Relationship between Visuospatial Impairments and Retinal and Cortical Thickness in Parkinson’s Disease

The paper touches upon current views on the pathophysiology of visuospatial impairments in Parkinson’s disease (PD). To assess thickness of retina’s ganglionic layer, retinal nerve fiber layer, and macular map, optical coherence tomography method was used. Brain MRI was also performed followed by ev...

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Bibliographic Details
Published inHuman physiology Vol. 43; no. 8; pp. 863 - 869
Main Authors Litvinenko, I. V., Boyko, E. V., Kulikov, A. N., Dynin, P. S., Trufanov, A. G., Mal’tsev, D. S., Yurin, A. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.12.2017
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Cognitive ability
Cortex (somatosensory)
Human Physiology
Life Sciences
Magnetic resonance imaging
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Retina
Visual cortex
cognitive deficit
MRI morphometry
optical coherence tomography
visuospatial impairments
Parkinson’s disease
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Summary:The paper touches upon current views on the pathophysiology of visuospatial impairments in Parkinson’s disease (PD). To assess thickness of retina’s ganglionic layer, retinal nerve fiber layer, and macular map, optical coherence tomography method was used. Brain MRI was also performed followed by evaluation of the cortical thickness. Patients underwent neuropsychological tests, including those for assessment of visuospatial perception and cognitive functions. We found certain retinal regions and areas of visual cortex with significant changes in PD patients on different stages. Our findings allowed us to speculate on the role of changes in the peripheral and central structures of the visual sensory system in the pathophysiology of visuospatial impairments in PD.
ISSN:0362-1197
1608-3164
DOI:10.1134/S0362119717080072