Using SEM to design a new generation of drug forms

Detailed study and understanding of the processes that occur during the cooling and subsequent annealing of frozen solutions of drugs in two-component systems of low boiling point liquids and water with clathrate formation requires the active involvement of scanning electron microscopy (SEM) to sele...

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Bibliographic Details
Published inBulletin of the Russian Academy of Sciences. Physics Vol. 78; no. 9; pp. 868 - 873
Main Authors Ogienko, A. A., Myz, S. A., Boldyreva, E. V., Zevak, E. G., Ogienko, A. G., Manakov, A. Yu, Ancharov, A. I., Kuchumov, B. M., Krasnikov, A. A.
Format Journal Article
LanguageEnglish
Published Heidelberg Allerton Press 01.09.2014
Springer Nature B.V
Subjects
Boiling points
Cooling systems
Dosage
Drug dosages
Drugs
Freeze drying
Freezing
Hadrons
Heavy Ions
Nuclear Physics
Pharmacology
Physics
Physics and Astronomy
Proceedings of the XVIII Russian Symposium on Scanning Electron Microscopy and Analytical Methods of Investigation Used in Solid-State Physics SEM-2013
Scanning electron microscopy
Initial Substance
Clathrate
Scale Interval
Freeze Solution
Ibuprofen
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Summary:Detailed study and understanding of the processes that occur during the cooling and subsequent annealing of frozen solutions of drugs in two-component systems of low boiling point liquids and water with clathrate formation requires the active involvement of scanning electron microscopy (SEM) to select the optimum conditions for freeze drying and comparative analysis of samples, forms of dosage, and initial substances. A new way of creating ultrafine forms of drugs and pharmaceutical compositions by freeze drying that can easily be extended to almost all modern low-dosage drugs to improve their pharmacokinetic profile and technological properties is developed.
ISSN:1062-8738
1934-9432
DOI:10.3103/S1062873814090202