The effects of testosterone and β-estradiol on activation of lymphocytes associated with IL-2 production and expression of CD25 (IL-2Rα)

• Published in: Cell and tissue biology Vol. 8; no. 6; pp. 473 - 477
• Main Authors: Gutsol, A. A., Sokhonevich, N. A., Kofanova, K. A., Litvinova, L. S.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 2014; Springer Nature B.V
• Subjects: 17β-Estradiol; Biomedical and Life Sciences; CD25 antigen; CD45RA antigen; Cell activation; Cell Biology; Interleukin 2; Interleukin 2 receptors; Life Sciences; Lymphocytes; Lymphocytes T; Testosterone; β-estradiol; testosterone; primed T memory cells; activation of cells; naive T lymphocytes
• ISSN: 1990-519X; 1990-5203
• DOI: 10.1134/S1990519X14060030

We carried out an in vitro study to examine the effects of testosterone and β-estradiol on activation of naive (CD45RA + ) and primed (CD45RO + ) T cells based on the production of IL-2 and expression of the CD25 (IL-2Rα) molecule. We determined that, overall, testosterone exerts an inhibitory effect on the functional activity of both naive and primed T cells. Naive cells were more sensitive to the testosterone effects, than primed lymphocytes. We identified a dose-dependent suppressive effect of β-estradiol on production of IL-2 by the activated CD45RA + and CD45RO + lymphocytes in the course of a uniform decrease in the number of CD25-positive T cells.