Sirtuin Functions in the Brain：From Physiological to Pathological Aspects

Sirtuins are a family of nicotinamide adenine dinucleotide（NAD＋） dependent deacetylases involved in multiple biological functions including metabolism, inflammation, stress resistance and aging. In mammals,there are seven members（Sirt1—Sirt7）, with diversities in their subcellular localizations and...

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Published inShanghai jiao tong da xue xue bao Vol. 19; no. 6; pp. 651 - 662
Main Author 邵家骧 张婷婷 刘腾远 全亦周 李凡 刘杰 杨霄 谢谦 夏伟梁
Format Journal Article
LanguageEnglish
Published Heidelberg Shanghai Jiaotong University Press 01.12.2014
Subjects
Architecture
Computer Science
Electrical Engineering
Engineering
Life Sciences
Materials Science
neurodegeneration
neural development
sirtuin
hypothalamic function
stroke
Q 189
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Summary:Sirtuins are a family of nicotinamide adenine dinucleotide（NAD＋） dependent deacetylases involved in multiple biological functions including metabolism, inflammation, stress resistance and aging. In mammals,there are seven members（Sirt1—Sirt7）, with diversities in their subcellular localizations and enzymatic activities.Here, we review the functions of sirtuins, with a focus on their roles in normal brain physiology such as neural development regulation, body homeostasis maintenance, and memory formation. We also discuss the role of sirtuins in a variety of brain diseases including stroke, Alzheimer＇s, Parkinson＇s, and motor neuron dysfunction.Because of the emerging functions of sirtuins in brain physiology and pathology, drugs targeting sirtuins may offer potential therapeutic values for brain disorders.
Bibliography:Sirtuins are a family of nicotinamide adenine dinucleotide（NAD＋） dependent deacetylases involved in multiple biological functions including metabolism, inflammation, stress resistance and aging. In mammals,there are seven members（Sirt1—Sirt7）, with diversities in their subcellular localizations and enzymatic activities.Here, we review the functions of sirtuins, with a focus on their roles in normal brain physiology such as neural development regulation, body homeostasis maintenance, and memory formation. We also discuss the role of sirtuins in a variety of brain diseases including stroke, Alzheimer＇s, Parkinson＇s, and motor neuron dysfunction.Because of the emerging functions of sirtuins in brain physiology and pathology, drugs targeting sirtuins may offer potential therapeutic values for brain disorders.
31-1943/U
sirtuin; neural development; hypothalamic function; stroke; neurodegeneration
SHAO Jia-xiang,ZHANG Ting-ting,LIU Teng-yuan,QUAN Yi-zhou,LI Fan,LIU Jie,YANG Xiao,XIE Qian,XIA Wei-liang（1. State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical-Stem Cell Research Center Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China; 2. School of Biomedical Engineering, Shanghai Jiaotong University, Shanghai 200240, China; 3. Med-X Research Institute, Shanghai Jiaotong University, Shanghai 200030, China）
ISSN:1007-1172
1995-8188
DOI:10.1007/s12204-014-1562-y