The strong in vitro and vivo cytotoxicity of three new cobalt(II) complexes with 8-methoxyquinoline
Three new cobalt(II) complexes, [Co(MQL) Cl ] (CoCl), [Co(MQL) Br ] (CoBr), and [Co(MQL) I ] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resi...
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Published in | Dalton transactions : an international journal of inorganic chemistry Vol. 51; no. 22; pp. 8840 - 8847 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society of Chemistry
07.06.2022
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Abstract | Three new cobalt(II) complexes, [Co(MQL)
Cl
] (CoCl), [Co(MQL)
Br
] (CoBr), and [Co(MQL)
I
] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resistant SK-OV-3/DDP and SK-OV-3 ovarian cancer cells, with IC
values of as low as 0.32-5.49 μM. Further, CoCl and CoI can regulate autophagy-related proteins in SK-OV-3/DDP cells and, therefore, they can induce primarily autophagy-mediated cell apoptosis in the following order: CoCl > CoI. The different antiproliferative activities of the MQL complexes CoCl, CoBr, and CoI could be correlated with the lengths of their Co-X bonds, which adopted the following order: CoI > CoBr > CoCl. The 8-HOMQ complexes CoCl (
60.1%) and CoI (
48.8%) also showed potent
anticancer effects after 15 days of treatment. In summary, the MQL ligand highly enhances the antiproliferative activities of cobalt(II) complexes in comparison to other previously reported 8-hydroxyquinoline metal complexes. |
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AbstractList | Three new cobalt(
ii
) complexes, [Co(MQL)
2
Cl
2
] (CoCl), [Co(MQL)
2
Br
2
] (CoBr), and [Co(MQL)
2
I
2
] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resistant SK-OV-3/DDP and SK-OV-3 ovarian cancer cells, with IC
50
values of as low as 0.32–5.49 μM. Further, CoCl and CoI can regulate autophagy-related proteins in SK-OV-3/DDP cells and, therefore, they can induce primarily autophagy-mediated cell apoptosis in the following order: CoCl > CoI. The different antiproliferative activities of the MQL complexes CoCl, CoBr, and CoI could be correlated with the lengths of their Co–X bonds, which adopted the following order: CoI > CoBr > CoCl. The 8-HOMQ complexes CoCl (
ca.
60.1%) and CoI (
ca.
48.8%) also showed potent
in vivo
anticancer effects after 15 days of treatment. In summary, the MQL ligand highly enhances the antiproliferative activities of cobalt(
ii
) complexes in comparison to other previously reported 8-hydroxyquinoline metal complexes. Three new cobalt(II) complexes, [Co(MQL) Cl ] (CoCl), [Co(MQL) Br ] (CoBr), and [Co(MQL) I ] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resistant SK-OV-3/DDP and SK-OV-3 ovarian cancer cells, with IC values of as low as 0.32-5.49 μM. Further, CoCl and CoI can regulate autophagy-related proteins in SK-OV-3/DDP cells and, therefore, they can induce primarily autophagy-mediated cell apoptosis in the following order: CoCl > CoI. The different antiproliferative activities of the MQL complexes CoCl, CoBr, and CoI could be correlated with the lengths of their Co-X bonds, which adopted the following order: CoI > CoBr > CoCl. The 8-HOMQ complexes CoCl ( 60.1%) and CoI ( 48.8%) also showed potent anticancer effects after 15 days of treatment. In summary, the MQL ligand highly enhances the antiproliferative activities of cobalt(II) complexes in comparison to other previously reported 8-hydroxyquinoline metal complexes. Three new cobalt(ii) complexes, [Co(MQL)2Cl2] (CoCl), [Co(MQL)2Br2] (CoBr), and [Co(MQL)2I2] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resistant SK-OV-3/DDP and SK-OV-3 ovarian cancer cells, with IC50 values of as low as 0.32–5.49 μM. Further, CoCl and CoI can regulate autophagy-related proteins in SK-OV-3/DDP cells and, therefore, they can induce primarily autophagy-mediated cell apoptosis in the following order: CoCl > CoI. The different antiproliferative activities of the MQL complexes CoCl, CoBr, and CoI could be correlated with the lengths of their Co–X bonds, which adopted the following order: CoI > CoBr > CoCl. The 8-HOMQ complexes CoCl (ca. 60.1%) and CoI (ca. 48.8%) also showed potent in vivo anticancer effects after 15 days of treatment. In summary, the MQL ligand highly enhances the antiproliferative activities of cobalt(ii) complexes in comparison to other previously reported 8-hydroxyquinoline metal complexes. |
Author | Liang, Fu-Pei Li, Juan Tang, Ji-Xia Mo, Zai-Yong Zou, Hua-Hong Wang, Yu-Feng |
Author_xml | – sequence: 1 givenname: Yu-Feng surname: Wang fullname: Wang, Yu-Feng email: gxnuchem@foxmail.com organization: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy of Guangxi Normal University, Guilin 541004, P. R. China. gxnuchem@foxmail.com – sequence: 2 givenname: Ji-Xia surname: Tang fullname: Tang, Ji-Xia organization: School of Foreign Language and International Business, Guilin University of Aerospace Technology, Guilin, 541004, P. R. China – sequence: 3 givenname: Zai-Yong surname: Mo fullname: Mo, Zai-Yong email: xdmozy@163.com organization: Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin 537000, PR China. xdmozy@163.com – sequence: 4 givenname: Juan surname: Li fullname: Li, Juan email: gxnuchem@foxmail.com organization: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy of Guangxi Normal University, Guilin 541004, P. R. China. gxnuchem@foxmail.com – sequence: 5 givenname: Fu-Pei surname: Liang fullname: Liang, Fu-Pei email: gxnuchem@foxmail.com organization: Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, P. R. China – sequence: 6 givenname: Hua-Hong orcidid: 0000-0003-1759-3714 surname: Zou fullname: Zou, Hua-Hong email: gxnuchem@foxmail.com organization: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy of Guangxi Normal University, Guilin 541004, P. R. China. gxnuchem@foxmail.com |
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Cites_doi | 10.1039/c3dt51720a 10.1039/C2DT32429F 10.1016/j.ccr.2009.01.028 10.1016/j.ejmech.2019.111727 10.1038/nchembio794 10.1039/C9DT04594E 10.1039/D1DT02765D 10.3109/09637486.2014.937801 10.1039/c2dt12274j 10.1039/C8TB01365A 10.1039/C3MT00237C 10.1021/acs.inorgchem.1c03451 10.1039/D0NJ04753H 10.1039/C9DT03330K 10.2174/092986706776872970 10.1039/D1DT04095B 10.1039/D0CC00524J 10.1016/j.ejmech.2018.07.016 10.1016/j.ejmech.2014.12.052 10.1002/ejic.201600908 10.1007/s11243-020-00399-4 10.1039/D0CS00173B 10.1039/C5DT02101D 10.1080/15548627.2018.1528812 10.1002/jhet.304 10.1039/C7DT04790H 10.1039/C9SC06460E 10.1016/j.molstruc.2009.07.026 10.1016/j.ejmech.2019.02.066 10.1039/C9DT00866G 10.1016/j.ejmech.2020.112535 10.1021/ic400538c 10.1039/D1DT03749H 10.1021/acs.inorgchem.7b01368 10.1021/acs.inorgchem.8b00433 10.1038/nrd1691 10.1039/C6DT03660K 10.1016/j.ejmech.2020.112192 10.1039/C9DT02381J 10.1021/ic049091h 10.1021/jm301053a 10.1039/c3sc51530c 10.1039/c3cc42250j 10.1016/j.molstruc.2020.129402 10.1039/D1DT04144D 10.1016/j.jinorgbio.2021.111453 10.1021/acs.inorgchem.8b03305 10.1021/acs.inorgchem.7b00710 10.1002/chem.201901569 10.1039/C9DT00322C 10.1039/D1DT02909F 10.1021/acs.inorgchem.6b00402 10.1021/acs.jmedchem.2c00133 10.1039/D1DT02825A 10.1039/C6NJ02899C 10.1021/jm301103y 10.1039/C5SC00125K 10.1039/b706075k 10.1016/j.bioorg.2019.102963 10.1016/j.jinorgbio.2019.110696 10.1016/j.bioorg.2019.103561 10.1021/jm400722d 10.1021/jm501043s 10.1039/D2DT00669C 10.1021/acs.inorgchem.8b03386 10.1016/j.molstruc.2020.128585 10.1021/acs.inorgchem.8b02250 10.1021/acsmedchemlett.9b00356 10.1021/acsomega.9b01781 10.1039/C7RA05504H 10.1016/j.msec.2018.12.080 10.1039/C6MT00275G 10.1039/D0NJ00465K 10.1107/S2053229620006701 10.1016/j.jinorgbio.2015.08.008 10.1039/C6MD00073H 10.1039/D1DT04120G 10.1016/j.ejmech.2022.114418 10.1016/j.ejmech.2018.04.044 10.1039/c9mt00037b 10.1039/C8DT00586A 10.1039/C4DT00463A 10.1016/j.bioorg.2021.104633 10.1039/D1DT02416G 10.1039/D2QI00205A 10.1016/j.ccr.2021.214210 10.1016/j.ejmech.2016.08.063 10.1073/pnas.1402228111 10.1021/ic4006967 10.1016/j.ejmech.2018.02.012 10.1021/acs.jmedchem.0c01875 10.1039/D1DT00450F 10.1016/j.ccr.2017.11.027 10.1038/222385a0 10.1021/jacs.6b05302 10.1039/D0SC02676J 10.1016/j.ejmech.2018.10.051 10.1038/s41419-021-04453-6 10.1016/j.ejmech.2018.04.013 |
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References | Zhao (D2DT01310J/cit3b/1) 2021; 50 Zou (D2DT01310J/cit18d/1) 2019; 58 Santos (D2DT01310J/cit18c/1) 2013; 42 Gobec (D2DT01310J/cit19b/1) 2014; 43 Wang (D2DT01310J/cit1d/1) 2022; 238 Kwon (D2DT01310J/cit7/1) 2020; 11 Li (D2DT01310J/cit33e/1) 2018; 156 Icsel (D2DT01310J/cit11/1) 2020; 202 Angeles-Boza (D2DT01310J/cit5a/1) 2004; 43 Li (D2DT01310J/cit31a/1) 2019; 58 Qin (D2DT01310J/cit29a/1) 2015; 92 Bisceglie (D2DT01310J/cit24/1) 2015; 152 Qin (D2DT01310J/cit30d/1) 2020; 56 Glenister (D2DT01310J/cit15b/1) 2021; 64 Qin (D2DT01310J/cit25b/1) 2019; 11 Glenister (D2DT01310J/cit15d/1) 2017; 9 Panja (D2DT01310J/cit14a/1) 2016; 55 Wang (D2DT01310J/cit4c/1) 2005; 4 Geng (D2DT01310J/cit32g/1) 2022; 13 Qin (D2DT01310J/cit10/1) 2016; 124 Li (D2DT01310J/cit9c/1) 2017; 7 Qin (D2DT01310J/cit33f/1) 2019; 48 Shimoda (D2DT01310J/cit16/1) 2018; 57 Tanaka (D2DT01310J/cit5b/1) 2005; 14 Qin (D2DT01310J/cit30e/1) 2019; 183 Khan (D2DT01310J/cit9a/1) 2019; 88 Wang (D2DT01310J/cit22c/1) 2020; 45 Wang (D2DT01310J/cit2d/1) 2022; 51 O'Neill (D2DT01310J/cit15a/1) 2017; 56 Meng (D2DT01310J/cit22f/1) 2019; 169 Deka (D2DT01310J/cit18a/1) 2017; 46 Heidary (D2DT01310J/cit18e/1) 2014; 57 Qin (D2DT01310J/cit22e/1) 2020; 44 Zhang (D2DT01310J/cit32e/1) 2018; 151 Meng (D2DT01310J/cit25a/1) 2019; 48 Wang (D2DT01310J/cit26b/1) 2022; 51 Alkış (D2DT01310J/cit8b/1) 2021; 1226 Gupta (D2DT01310J/cit18f/1) 2021; 108 Havrylyuk (D2DT01310J/cit19a/1) 2018; 156 Oliveri (D2DT01310J/cit20b/1) 2013; 42 Zhang (D2DT01310J/cit27b/1) 2016; 7 Frei (D2DT01310J/cit3d/1) 2020; 11 King (D2DT01310J/cit1a/1) 2017; 56 Jana (D2DT01310J/cit4e/1) 2022; 51 Qin (D2DT01310J/cit22b/1) 2019; 161 Hambley (D2DT01310J/cit2b/1) 2007 Johnstone (D2DT01310J/cit1c/1) 2013; 52 Renfrew (D2DT01310J/cit6a/1) 2018; 375 Fang (D2DT01310J/cit4d/1) 2019; 58 Arnesano (D2DT01310J/cit2c/1) 2009; 253 Renfrew (D2DT01310J/cit15c/1) 2013; 4 Shao (D2DT01310J/cit22d/1) 2020; 44 Madonna (D2DT01310J/cit29b/1) 2010; 47 Dolara (D2DT01310J/cit6b/1) 2014; 65 Çolak (D2DT01310J/cit27e/1) 2009; 936 Raja (D2DT01310J/cit14b/1) 2012; 41 Obermoser (D2DT01310J/cit30b/1) 2018; 47 Abu-Surrah (D2DT01310J/cit1b/1) 2006; 13 Meng (D2DT01310J/cit21c/1) 2020; 192 Rosenberg (D2DT01310J/cit4b/1) 1969; 222 Tardito (D2DT01310J/cit22a/1) 2012; 55 Peng (D2DT01310J/cit3c/1) 2021; 449 Yang (D2DT01310J/cit21b/1) 2021; 50 Lee (D2DT01310J/cit32c/1) 2019; 15 Tang (D2DT01310J/cit18b/1) 2013; 49 Matlack (D2DT01310J/cit20a/1) 2014; 111 Nam (D2DT01310J/cit30g/1) 2016; 138 Shiga (D2DT01310J/cit17/1) 2018; 47 Deng (D2DT01310J/cit28b/1) 2020; 76 Zhang (D2DT01310J/cit3e/1) 2017 Ruehl (D2DT01310J/cit8d/1) 2019; 25 Jiang (D2DT01310J/cit33a/1) 2022; 51 Baecker (D2DT01310J/cit30f/1) 2019; 48 Meng (D2DT01310J/cit27c/1) 2019; 10 Ng (D2DT01310J/cit30c/1) 2021; 220 He (D2DT01310J/cit32b/1) 2019; 48 Yang (D2DT01310J/cit26a/1) 2021; 50 Sobiesiak (D2DT01310J/cit30a/1) 2016; 40 Ahamad (D2DT01310J/cit8c/1) 2020; 95 Huang (D2DT01310J/cit33d/1) 2018; 148 Yang (D2DT01310J/cit23/1) 2014; 6 Chen (D2DT01310J/cit8a/1) 2022; 51 Shamle (D2DT01310J/cit27d/1) 2020; 1219 Karumban (D2DT01310J/cit4a/1) 2022; 51 Zhao (D2DT01310J/cit2a/1) 2019; 197 Castonguay (D2DT01310J/cit32d/1) 2012; 55 Ma (D2DT01310J/cit28a/1) 2019; 4 Li (D2DT01310J/cit6c/1) 2021; 50 Şen (D2DT01310J/cit12/1) 2019; 98 Ma (D2DT01310J/cit3a/1) 2022 Jia (D2DT01310J/cit21a/1) 2013; 56 Chang (D2DT01310J/cit27a/1) 2013; 52 Xie (D2DT01310J/cit13/1) 2022; 61 Kumar (D2DT01310J/cit31b/1) 2018; 6 Shen (D2DT01310J/cit32a/1) 2022; 65 Tan (D2DT01310J/cit33b/1) 2020; 49 Munteanu (D2DT01310J/cit9b/1) 2015; 44 Lim (D2DT01310J/cit30h/1) 2006; 2 Gu (D2DT01310J/cit33c/1) 2022; 51 Zamudio-Vazquez (D2DT01310J/cit32f/1) 2015; 6 |
References_xml | – volume: 42 start-page: 13343 year: 2013 ident: D2DT01310J/cit18c/1 publication-title: Dalton Trans. doi: 10.1039/c3dt51720a contributor: fullname: Santos – volume: 42 start-page: 2023 year: 2013 ident: D2DT01310J/cit20b/1 publication-title: Dalton Trans. doi: 10.1039/C2DT32429F contributor: fullname: Oliveri – volume: 253 start-page: 2070 year: 2009 ident: D2DT01310J/cit2c/1 publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2009.01.028 contributor: fullname: Arnesano – volume: 183 start-page: 111727 year: 2019 ident: D2DT01310J/cit30e/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2019.111727 contributor: fullname: Qin – volume: 2 start-page: 375 year: 2006 ident: D2DT01310J/cit30h/1 publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio794 contributor: fullname: Lim – volume: 49 start-page: 1613 year: 2020 ident: D2DT01310J/cit33b/1 publication-title: Dalton Trans. doi: 10.1039/C9DT04594E contributor: fullname: Tan – volume: 51 start-page: 1333 year: 2022 ident: D2DT01310J/cit33c/1 publication-title: Dalton Trans. doi: 10.1039/D1DT02765D contributor: fullname: Gu – volume: 65 start-page: 911 year: 2014 ident: D2DT01310J/cit6b/1 publication-title: Int. J. Food Sci. Nutr. doi: 10.3109/09637486.2014.937801 contributor: fullname: Dolara – volume: 41 start-page: 4365 year: 2012 ident: D2DT01310J/cit14b/1 publication-title: Dalton Trans. doi: 10.1039/c2dt12274j contributor: fullname: Raja – volume: 6 start-page: 5385 year: 2018 ident: D2DT01310J/cit31b/1 publication-title: J. Mater. Chem. B doi: 10.1039/C8TB01365A contributor: fullname: Kumar – volume: 6 start-page: 518 year: 2014 ident: D2DT01310J/cit23/1 publication-title: Metallomics doi: 10.1039/C3MT00237C contributor: fullname: Yang – volume: 61 start-page: 2204 year: 2022 ident: D2DT01310J/cit13/1 publication-title: Inorg. Chem. doi: 10.1021/acs.inorgchem.1c03451 contributor: fullname: Xie – volume: 44 start-page: 19885 year: 2020 ident: D2DT01310J/cit22d/1 publication-title: New J. Chem. doi: 10.1039/D0NJ04753H contributor: fullname: Shao – volume: 48 start-page: 15856 year: 2019 ident: D2DT01310J/cit30f/1 publication-title: Dalton Trans. doi: 10.1039/C9DT03330K contributor: fullname: Baecker – volume: 13 start-page: 1337 year: 2006 ident: D2DT01310J/cit1b/1 publication-title: Curr. Med. Chem. doi: 10.2174/092986706776872970 contributor: fullname: Abu-Surrah – volume: 51 start-page: 5024 year: 2022 ident: D2DT01310J/cit2d/1 publication-title: Dalton Trans. doi: 10.1039/D1DT04095B contributor: fullname: Wang – volume: 56 start-page: 3999 year: 2020 ident: D2DT01310J/cit30d/1 publication-title: Chem. Commun. doi: 10.1039/D0CC00524J contributor: fullname: Qin – volume: 156 start-page: 666 year: 2018 ident: D2DT01310J/cit33e/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2018.07.016 contributor: fullname: Li – volume: 92 start-page: 302 year: 2015 ident: D2DT01310J/cit29a/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2014.12.052 contributor: fullname: Qin – start-page: 1541 year: 2017 ident: D2DT01310J/cit3e/1 publication-title: Eur. J. Inorg. Chem. doi: 10.1002/ejic.201600908 contributor: fullname: Zhang – volume: 45 start-page: 477 year: 2020 ident: D2DT01310J/cit22c/1 publication-title: Transition Met. Chem. doi: 10.1007/s11243-020-00399-4 contributor: fullname: Wang – volume: 50 start-page: 4185 year: 2021 ident: D2DT01310J/cit3b/1 publication-title: Chem. Soc. Rev. doi: 10.1039/D0CS00173B contributor: fullname: Zhao – volume: 44 start-page: 13796 year: 2015 ident: D2DT01310J/cit9b/1 publication-title: Dalton Trans. doi: 10.1039/C5DT02101D contributor: fullname: Munteanu – volume: 15 start-page: 543 year: 2019 ident: D2DT01310J/cit32c/1 publication-title: Autophagy doi: 10.1080/15548627.2018.1528812 contributor: fullname: Lee – volume: 47 start-page: 719 year: 2010 ident: D2DT01310J/cit29b/1 publication-title: J. Heterocycl. Chem. doi: 10.1002/jhet.304 contributor: fullname: Madonna – volume: 47 start-page: 4341 year: 2018 ident: D2DT01310J/cit30b/1 publication-title: Dalton Trans. doi: 10.1039/C7DT04790H contributor: fullname: Obermoser – volume: 11 start-page: 2627 year: 2020 ident: D2DT01310J/cit3d/1 publication-title: Chem. Sci. doi: 10.1039/C9SC06460E contributor: fullname: Frei – volume: 936 start-page: 67 year: 2009 ident: D2DT01310J/cit27e/1 publication-title: J. Mol. Struct. doi: 10.1016/j.molstruc.2009.07.026 contributor: fullname: Çolak – volume: 169 start-page: 103 year: 2019 ident: D2DT01310J/cit22f/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2019.02.066 contributor: fullname: Meng – volume: 48 start-page: 5352 year: 2019 ident: D2DT01310J/cit25a/1 publication-title: Dalton Trans. doi: 10.1039/C9DT00866G contributor: fullname: Meng – volume: 202 start-page: 112535 year: 2020 ident: D2DT01310J/cit11/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2020.112535 contributor: fullname: Icsel – volume: 52 start-page: 12234 year: 2013 ident: D2DT01310J/cit1c/1 publication-title: Inorg. Chem. doi: 10.1021/ic400538c contributor: fullname: Johnstone – volume: 51 start-page: 4068 year: 2022 ident: D2DT01310J/cit8a/1 publication-title: Dalton Trans. doi: 10.1039/D1DT03749H contributor: fullname: Chen – volume: 56 start-page: 9860 year: 2017 ident: D2DT01310J/cit15a/1 publication-title: Inorg. Chem. doi: 10.1021/acs.inorgchem.7b01368 contributor: fullname: O'Neill – volume: 57 start-page: 5486 year: 2018 ident: D2DT01310J/cit16/1 publication-title: Inorg. Chem. doi: 10.1021/acs.inorgchem.8b00433 contributor: fullname: Shimoda – volume: 4 start-page: 307 year: 2005 ident: D2DT01310J/cit4c/1 publication-title: Nat. Rev. Drug Discovery doi: 10.1038/nrd1691 contributor: fullname: Wang – volume: 46 start-page: 396 year: 2017 ident: D2DT01310J/cit18a/1 publication-title: Dalton Trans. doi: 10.1039/C6DT03660K contributor: fullname: Deka – volume: 192 start-page: 112192 year: 2020 ident: D2DT01310J/cit21c/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2020.112192 contributor: fullname: Meng – volume: 48 start-page: 15247 year: 2019 ident: D2DT01310J/cit33f/1 publication-title: Dalton Trans. doi: 10.1039/C9DT02381J contributor: fullname: Qin – volume: 43 start-page: 8510 year: 2004 ident: D2DT01310J/cit5a/1 publication-title: Inorg. Chem. doi: 10.1021/ic049091h contributor: fullname: Angeles-Boza – volume: 55 start-page: 10448 year: 2012 ident: D2DT01310J/cit22a/1 publication-title: J. Med. Chem. doi: 10.1021/jm301053a contributor: fullname: Tardito – volume: 4 start-page: 3731 year: 2013 ident: D2DT01310J/cit15c/1 publication-title: Chem. Sci. doi: 10.1039/c3sc51530c contributor: fullname: Renfrew – volume: 49 start-page: 9980 year: 2013 ident: D2DT01310J/cit18b/1 publication-title: Chem. Commun. doi: 10.1039/c3cc42250j contributor: fullname: Tang – volume: 1226 start-page: 129402 year: 2021 ident: D2DT01310J/cit8b/1 publication-title: J. Mol. Struct. doi: 10.1016/j.molstruc.2020.129402 contributor: fullname: Alkış – volume: 51 start-page: 7084 year: 2022 ident: D2DT01310J/cit4a/1 publication-title: Dalton Trans. doi: 10.1039/D1DT04144D contributor: fullname: Karumban – volume: 220 start-page: 111453 year: 2021 ident: D2DT01310J/cit30c/1 publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2021.111453 contributor: fullname: Ng – volume: 58 start-page: 1710 year: 2019 ident: D2DT01310J/cit31a/1 publication-title: Inorg. Chem. doi: 10.1021/acs.inorgchem.8b03305 contributor: fullname: Li – volume: 56 start-page: 6609 year: 2017 ident: D2DT01310J/cit1a/1 publication-title: Inorg. Chem. doi: 10.1021/acs.inorgchem.7b00710 contributor: fullname: King – volume: 25 start-page: 9691 year: 2019 ident: D2DT01310J/cit8d/1 publication-title: Chem. – Eur. J. doi: 10.1002/chem.201901569 contributor: fullname: Ruehl – volume: 48 start-page: 4398 year: 2019 ident: D2DT01310J/cit32b/1 publication-title: Dalton Trans. doi: 10.1039/C9DT00322C contributor: fullname: He – volume: 50 start-page: 14498 year: 2021 ident: D2DT01310J/cit6c/1 publication-title: Dalton Trans. doi: 10.1039/D1DT02909F contributor: fullname: Li – volume: 55 start-page: 8331 year: 2016 ident: D2DT01310J/cit14a/1 publication-title: Inorg. Chem. doi: 10.1021/acs.inorgchem.6b00402 contributor: fullname: Panja – volume: 65 start-page: 5134 year: 2022 ident: D2DT01310J/cit32a/1 publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.2c00133 contributor: fullname: Shen – volume: 51 start-page: 2346 year: 2022 ident: D2DT01310J/cit4e/1 publication-title: Dalton Trans. doi: 10.1039/D1DT02825A contributor: fullname: Jana – volume: 40 start-page: 9761 year: 2016 ident: D2DT01310J/cit30a/1 publication-title: New J. Chem. doi: 10.1039/C6NJ02899C contributor: fullname: Sobiesiak – volume: 55 start-page: 8799 year: 2012 ident: D2DT01310J/cit32d/1 publication-title: J. Med. Chem. doi: 10.1021/jm301103y contributor: fullname: Castonguay – volume: 6 start-page: 4537 year: 2015 ident: D2DT01310J/cit32f/1 publication-title: Chem. Sci. doi: 10.1039/C5SC00125K contributor: fullname: Zamudio-Vazquez – start-page: 4929 year: 2007 ident: D2DT01310J/cit2b/1 publication-title: Dalton Trans. doi: 10.1039/b706075k contributor: fullname: Hambley – volume: 88 start-page: 102963 year: 2019 ident: D2DT01310J/cit9a/1 publication-title: Bioorg. Chem. doi: 10.1016/j.bioorg.2019.102963 contributor: fullname: Khan – volume: 197 start-page: 110696 year: 2019 ident: D2DT01310J/cit2a/1 publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2019.110696 contributor: fullname: Zhao – volume: 95 start-page: 103561 year: 2020 ident: D2DT01310J/cit8c/1 publication-title: Bioorg. Chem. doi: 10.1016/j.bioorg.2019.103561 contributor: fullname: Ahamad – volume: 56 start-page: 5797 year: 2013 ident: D2DT01310J/cit21a/1 publication-title: J. Med. Chem. doi: 10.1021/jm400722d contributor: fullname: Jia – volume: 57 start-page: 8936 year: 2014 ident: D2DT01310J/cit18e/1 publication-title: J. Med. Chem. doi: 10.1021/jm501043s contributor: fullname: Heidary – volume: 51 start-page: 7154 year: 2022 ident: D2DT01310J/cit26b/1 publication-title: Dalton Trans. doi: 10.1039/D2DT00669C contributor: fullname: Wang – volume: 58 start-page: 2191 year: 2019 ident: D2DT01310J/cit4d/1 publication-title: Inorg. Chem. doi: 10.1021/acs.inorgchem.8b03386 contributor: fullname: Fang – volume: 1219 start-page: 128585 year: 2020 ident: D2DT01310J/cit27d/1 publication-title: J. Mol. Struct. doi: 10.1016/j.molstruc.2020.128585 contributor: fullname: Shamle – volume: 58 start-page: 2286 year: 2019 ident: D2DT01310J/cit18d/1 publication-title: Inorg. Chem. doi: 10.1021/acs.inorgchem.8b02250 contributor: fullname: Zou – volume: 10 start-page: 1603 year: 2019 ident: D2DT01310J/cit27c/1 publication-title: ACS Med. Chem. Lett. doi: 10.1021/acsmedchemlett.9b00356 contributor: fullname: Meng – volume: 4 start-page: 20905 year: 2019 ident: D2DT01310J/cit28a/1 publication-title: ACS Omega doi: 10.1021/acsomega.9b01781 contributor: fullname: Ma – volume: 7 start-page: 41527 year: 2017 ident: D2DT01310J/cit9c/1 publication-title: RSC Adv. doi: 10.1039/C7RA05504H contributor: fullname: Li – volume: 98 start-page: 550 year: 2019 ident: D2DT01310J/cit12/1 publication-title: Mater. Sci. Eng., C doi: 10.1016/j.msec.2018.12.080 contributor: fullname: Şen – volume: 9 start-page: 699 year: 2017 ident: D2DT01310J/cit15d/1 publication-title: Metallomics doi: 10.1039/C6MT00275G contributor: fullname: Glenister – volume: 44 start-page: 7832 year: 2020 ident: D2DT01310J/cit22e/1 publication-title: New J. Chem. doi: 10.1039/D0NJ00465K contributor: fullname: Qin – volume: 76 start-page: 655 year: 2020 ident: D2DT01310J/cit28b/1 publication-title: Acta Crystallogr., Sect. C: Struct. Chem. doi: 10.1107/S2053229620006701 contributor: fullname: Deng – volume: 152 start-page: 10 year: 2015 ident: D2DT01310J/cit24/1 publication-title: J. Inorg. Biochem. doi: 10.1016/j.jinorgbio.2015.08.008 contributor: fullname: Bisceglie – volume: 7 start-page: 806 year: 2016 ident: D2DT01310J/cit27b/1 publication-title: MedChemComm doi: 10.1039/C6MD00073H contributor: fullname: Zhang – volume: 51 start-page: 2798 year: 2022 ident: D2DT01310J/cit33a/1 publication-title: Dalton Trans. doi: 10.1039/D1DT04120G contributor: fullname: Jiang – volume: 238 start-page: 114418 year: 2022 ident: D2DT01310J/cit1d/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2022.114418 contributor: fullname: Wang – volume: 156 start-page: 790 year: 2018 ident: D2DT01310J/cit19a/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2018.04.044 contributor: fullname: Havrylyuk – volume: 11 start-page: 1005 year: 2019 ident: D2DT01310J/cit25b/1 publication-title: Metallomics doi: 10.1039/c9mt00037b contributor: fullname: Qin – volume: 47 start-page: 7804 year: 2018 ident: D2DT01310J/cit17/1 publication-title: Dalton Trans. doi: 10.1039/C8DT00586A contributor: fullname: Shiga – volume: 43 start-page: 9045 year: 2014 ident: D2DT01310J/cit19b/1 publication-title: Dalton Trans. doi: 10.1039/C4DT00463A contributor: fullname: Gobec – volume: 14 start-page: 1365 year: 2005 ident: D2DT01310J/cit5b/1 publication-title: Oncol. Rep. contributor: fullname: Tanaka – volume: 108 start-page: 104633 year: 2021 ident: D2DT01310J/cit18f/1 publication-title: Bioorg. Chem. doi: 10.1016/j.bioorg.2021.104633 contributor: fullname: Gupta – volume: 50 start-page: 16273 year: 2021 ident: D2DT01310J/cit21b/1 publication-title: Dalton Trans. doi: 10.1039/D1DT02416G contributor: fullname: Yang – year: 2022 ident: D2DT01310J/cit3a/1 publication-title: Inorg. Chem. Front. doi: 10.1039/D2QI00205A contributor: fullname: Ma – volume: 449 start-page: 214210 year: 2021 ident: D2DT01310J/cit3c/1 publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2021.214210 contributor: fullname: Peng – volume: 124 start-page: 380 year: 2016 ident: D2DT01310J/cit10/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2016.08.063 contributor: fullname: Qin – volume: 111 start-page: 4013 year: 2014 ident: D2DT01310J/cit20a/1 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1402228111 contributor: fullname: Matlack – volume: 52 start-page: 7688 year: 2013 ident: D2DT01310J/cit27a/1 publication-title: Inorg. Chem. doi: 10.1021/ic4006967 contributor: fullname: Chang – volume: 148 start-page: 1 year: 2018 ident: D2DT01310J/cit33d/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2018.02.012 contributor: fullname: Huang – volume: 64 start-page: 2678 year: 2021 ident: D2DT01310J/cit15b/1 publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.0c01875 contributor: fullname: Glenister – volume: 50 start-page: 5828 year: 2021 ident: D2DT01310J/cit26a/1 publication-title: Dalton Trans. doi: 10.1039/D1DT00450F contributor: fullname: Yang – volume: 375 start-page: 221 year: 2018 ident: D2DT01310J/cit6a/1 publication-title: Coord. Chem. Rev. doi: 10.1016/j.ccr.2017.11.027 contributor: fullname: Renfrew – volume: 222 start-page: 385 year: 1969 ident: D2DT01310J/cit4b/1 publication-title: Nature doi: 10.1038/222385a0 contributor: fullname: Rosenberg – volume: 138 start-page: 10968 year: 2016 ident: D2DT01310J/cit30g/1 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.6b05302 contributor: fullname: Nam – volume: 11 start-page: 9017 year: 2020 ident: D2DT01310J/cit7/1 publication-title: Chem. Sci. doi: 10.1039/D0SC02676J contributor: fullname: Kwon – volume: 161 start-page: 334 year: 2019 ident: D2DT01310J/cit22b/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2018.10.051 contributor: fullname: Qin – volume: 13 start-page: 7 year: 2022 ident: D2DT01310J/cit32g/1 publication-title: Cell Death Dis. doi: 10.1038/s41419-021-04453-6 contributor: fullname: Geng – volume: 151 start-page: 568 year: 2018 ident: D2DT01310J/cit32e/1 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2018.04.013 contributor: fullname: Zhang |
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Snippet | Three new cobalt(II) complexes, [Co(MQL)
Cl
] (CoCl), [Co(MQL)
Br
] (CoBr), and [Co(MQL)
I
] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the... Three new cobalt( ii ) complexes, [Co(MQL) 2 Cl 2 ] (CoCl), [Co(MQL) 2 Br 2 ] (CoBr), and [Co(MQL) 2 I 2 ] (CoI), bearing 8-methoxyquinoline (MQL) have been... Three new cobalt(ii) complexes, [Co(MQL)2Cl2] (CoCl), [Co(MQL)2Br2] (CoBr), and [Co(MQL)2I2] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the... |
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SubjectTerms | Anticancer properties Antiproliferatives Apoptosis Autophagy Biocompatibility Cobalt compounds Coordination compounds Hydroxyquinoline Toxicity |
Title | The strong in vitro and vivo cytotoxicity of three new cobalt(II) complexes with 8-methoxyquinoline |
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