The strong in vitro and vivo cytotoxicity of three new cobalt(II) complexes with 8-methoxyquinoline

Three new cobalt(II) complexes, [Co(MQL) Cl ] (CoCl), [Co(MQL) Br ] (CoBr), and [Co(MQL) I ] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resi...

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Published inDalton transactions : an international journal of inorganic chemistry Vol. 51; no. 22; pp. 8840 - 8847
Main Authors Wang, Yu-Feng, Tang, Ji-Xia, Mo, Zai-Yong, Li, Juan, Liang, Fu-Pei, Zou, Hua-Hong
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 07.06.2022
Subjects
Anticancer properties
Antiproliferatives
Apoptosis
Autophagy
Biocompatibility
Cobalt compounds
Coordination compounds
Hydroxyquinoline
Toxicity
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Abstract Three new cobalt(II) complexes, [Co(MQL) Cl ] (CoCl), [Co(MQL) Br ] (CoBr), and [Co(MQL) I ] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resistant SK-OV-3/DDP and SK-OV-3 ovarian cancer cells, with IC values of as low as 0.32-5.49 μM. Further, CoCl and CoI can regulate autophagy-related proteins in SK-OV-3/DDP cells and, therefore, they can induce primarily autophagy-mediated cell apoptosis in the following order: CoCl > CoI. The different antiproliferative activities of the MQL complexes CoCl, CoBr, and CoI could be correlated with the lengths of their Co-X bonds, which adopted the following order: CoI > CoBr > CoCl. The 8-HOMQ complexes CoCl ( 60.1%) and CoI ( 48.8%) also showed potent anticancer effects after 15 days of treatment. In summary, the MQL ligand highly enhances the antiproliferative activities of cobalt(II) complexes in comparison to other previously reported 8-hydroxyquinoline metal complexes.
AbstractList Three new cobalt( ii ) complexes, [Co(MQL) 2 Cl 2 ] (CoCl), [Co(MQL) 2 Br 2 ] (CoBr), and [Co(MQL) 2 I 2 ] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resistant SK-OV-3/DDP and SK-OV-3 ovarian cancer cells, with IC 50 values of as low as 0.32–5.49 μM. Further, CoCl and CoI can regulate autophagy-related proteins in SK-OV-3/DDP cells and, therefore, they can induce primarily autophagy-mediated cell apoptosis in the following order: CoCl > CoI. The different antiproliferative activities of the MQL complexes CoCl, CoBr, and CoI could be correlated with the lengths of their Co–X bonds, which adopted the following order: CoI > CoBr > CoCl. The 8-HOMQ complexes CoCl ( ca. 60.1%) and CoI ( ca. 48.8%) also showed potent in vivo anticancer effects after 15 days of treatment. In summary, the MQL ligand highly enhances the antiproliferative activities of cobalt( ii ) complexes in comparison to other previously reported 8-hydroxyquinoline metal complexes.
Three new cobalt(II) complexes, [Co(MQL) Cl ] (CoCl), [Co(MQL) Br ] (CoBr), and [Co(MQL) I ] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resistant SK-OV-3/DDP and SK-OV-3 ovarian cancer cells, with IC values of as low as 0.32-5.49 μM. Further, CoCl and CoI can regulate autophagy-related proteins in SK-OV-3/DDP cells and, therefore, they can induce primarily autophagy-mediated cell apoptosis in the following order: CoCl > CoI. The different antiproliferative activities of the MQL complexes CoCl, CoBr, and CoI could be correlated with the lengths of their Co-X bonds, which adopted the following order: CoI > CoBr > CoCl. The 8-HOMQ complexes CoCl ( 60.1%) and CoI ( 48.8%) also showed potent anticancer effects after 15 days of treatment. In summary, the MQL ligand highly enhances the antiproliferative activities of cobalt(II) complexes in comparison to other previously reported 8-hydroxyquinoline metal complexes.
Three new cobalt(ii) complexes, [Co(MQL)2Cl2] (CoCl), [Co(MQL)2Br2] (CoBr), and [Co(MQL)2I2] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resistant SK-OV-3/DDP and SK-OV-3 ovarian cancer cells, with IC50 values of as low as 0.32–5.49 μM. Further, CoCl and CoI can regulate autophagy-related proteins in SK-OV-3/DDP cells and, therefore, they can induce primarily autophagy-mediated cell apoptosis in the following order: CoCl > CoI. The different antiproliferative activities of the MQL complexes CoCl, CoBr, and CoI could be correlated with the lengths of their Co–X bonds, which adopted the following order: CoI > CoBr > CoCl. The 8-HOMQ complexes CoCl (ca. 60.1%) and CoI (ca. 48.8%) also showed potent in vivo anticancer effects after 15 days of treatment. In summary, the MQL ligand highly enhances the antiproliferative activities of cobalt(ii) complexes in comparison to other previously reported 8-hydroxyquinoline metal complexes.
Author Liang, Fu-Pei
Li, Juan
Tang, Ji-Xia
Mo, Zai-Yong
Zou, Hua-Hong
Wang, Yu-Feng
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Snippet Three new cobalt(II) complexes, [Co(MQL) Cl ] (CoCl), [Co(MQL) Br ] (CoBr), and [Co(MQL) I ] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the...
Three new cobalt( ii ) complexes, [Co(MQL) 2 Cl 2 ] (CoCl), [Co(MQL) 2 Br 2 ] (CoBr), and [Co(MQL) 2 I 2 ] (CoI), bearing 8-methoxyquinoline (MQL) have been...
Three new cobalt(ii) complexes, [Co(MQL)2Cl2] (CoCl), [Co(MQL)2Br2] (CoBr), and [Co(MQL)2I2] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the...
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SubjectTerms Anticancer properties
Antiproliferatives
Apoptosis
Autophagy
Biocompatibility
Cobalt compounds
Coordination compounds
Hydroxyquinoline
Toxicity
Title The strong in vitro and vivo cytotoxicity of three new cobalt(II) complexes with 8-methoxyquinoline
URI https://www.ncbi.nlm.nih.gov/pubmed/35621165
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