The strong in vitro and vivo cytotoxicity of three new cobalt(II) complexes with 8-methoxyquinoline
Three new cobalt(II) complexes, [Co(MQL) Cl ] (CoCl), [Co(MQL) Br ] (CoBr), and [Co(MQL) I ] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resi...
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Published in | Dalton transactions : an international journal of inorganic chemistry Vol. 51; no. 22; pp. 8840 - 8847 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Royal Society of Chemistry
07.06.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Three new cobalt(II) complexes, [Co(MQL)
Cl
] (CoCl), [Co(MQL)
Br
] (CoBr), and [Co(MQL)
I
] (CoI), bearing 8-methoxyquinoline (MQL) have been designed for the first time. MTT assays showed that CoCl, CoBr, and CoI exhibit much better antiproliferative activities than cisplatin toward cisplatin-resistant SK-OV-3/DDP and SK-OV-3 ovarian cancer cells, with IC
values of as low as 0.32-5.49 μM. Further, CoCl and CoI can regulate autophagy-related proteins in SK-OV-3/DDP cells and, therefore, they can induce primarily autophagy-mediated cell apoptosis in the following order: CoCl > CoI. The different antiproliferative activities of the MQL complexes CoCl, CoBr, and CoI could be correlated with the lengths of their Co-X bonds, which adopted the following order: CoI > CoBr > CoCl. The 8-HOMQ complexes CoCl (
60.1%) and CoI (
48.8%) also showed potent
anticancer effects after 15 days of treatment. In summary, the MQL ligand highly enhances the antiproliferative activities of cobalt(II) complexes in comparison to other previously reported 8-hydroxyquinoline metal complexes. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1477-9226 1477-9234 |
DOI: | 10.1039/d2dt01310j |