Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr

Two new quassinoids (1 and 2) were isolated from the twigs of (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1α,12α:5α,13α-dicyclo-9βH-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly i...

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Published inOrganic & biomolecular chemistry Vol. 19; no. 44; pp. 9637 - 9640
Main Authors Liu, Shuai, Zhang, Cui-Shan, Ran, Xiao-Qian, Tang, Xiao-Han, Guo, Ya-Rong, Yan, Ying, Yao, Yong-Gang, Hao, Xiao-Jiang, Luo, Rong-Can, Di, Ying-Tong
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 18.11.2021
Subjects
Biosynthesis
Crystallography
Quassinoids
Simaroubaceae
Transcription activation
X-ray crystallography
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Summary:Two new quassinoids (1 and 2) were isolated from the twigs of (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1α,12α:5α,13α-dicyclo-9βH-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly induce lysosomal biogenesis through transcriptional activation of lysosomal genes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/d1ob01927a