Effect of dopamine receptor-related compounds on naive common marmosets for auditory steady state response

• Published in: Journal of neurophysiology Vol. 128; no. 1; pp. 229 - 238
• Main Authors: Iwamura, Yoshihiro, Nakayama, Tatsuo, Matsumoto, Atsushi, Ogi, Yuji, Yamaguchi, Masataka, Kobayashi, Atsushi, Matsumoto, Kenji, Katsura, Yasunori, Konoike, Naho, Nakamura, Katsuki, Ikeda, Kazuhito
• Format: Journal Article
• Language: English
• Published: United States 01.07.2022
• Subjects: rhesus monkey; auditory steady state response; Electroencephalography; opamine D1 receptor; dopamine D2 receptor
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.00147.2022

Abnormalities of auditory steady state responses (ASSR) and the effects of antipsychotic drugs on ASSR have been investigated in patients with schizophrenia. It is presumed that effects of drugs do not directly reflect on ASSR, because of ASSR abnormalities associated with schizophrenia. Therefore, to investigate the direct effect of drugs on ASSR, we established an ASSR evaluation system for common marmosets in a naïve state. Dopamine D1 receptor stimulation (SKF-81297, 2 mg/kg, intraperitoneal) significantly increased evoked power (EP) at 40 Hz. The phase locking factor (PLF) was increased significantly at 20, 30, 40, and 80 Hz. However, the administration of a dopamine D1 receptor antagonist (SCH-39166, 0.3 mg/kg intraperitoneal) resulted in a significant decrease in EP and PLF at 30 Hz. Dopamine D2 receptor stimulation (quinpirole, 1 mg/kg, intramuscular) tended to increase EP and induced power (IP) at all frequencies, and a significant difference was observed at 30 Hz IP. There was no change in PLF at all frequencies. In addition, dopamine D2 receptor blockade (raclopride, 3 mg/kg, intraperitoneal) reduced EP and PLF at 30 Hz. Subcutaneous administration of the serotonin dopamine antagonist, risperidone (0.3 mg/kg), tended to increase IP and decrease PLF, but not significantly. Taken together, it is possible to compare the differences in the mode of action of drugs on ASSR using naïve non-human primates.