SYNTHESIS OF NEW HYDANTOINS BEARING GLUTARIMIDE OR SUCCINIMIDE MOIETY AND THEIR EVALUATION FOR CELL DIFFERENTIATION-INDUCING AND ANTI-ANGIOGENIC ACTIVITIES

Several derivatives of hydantoin containing glutarimide or succinimide at the 3-position were synthesized. The new hydantoin derivatives had a structure similar to that of thalidomide, and so may possess activity similar to that of thalidomide and/or its analogs, such as effects on cell differentiat...

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Bibliographic Details
Published inHeterocycles Vol. 91; no. 4; pp. 764 - 781
Main Authors Yamaguchi, Jun-ichi, Noguchi-Yachide, Tomomi, Sakaguchi, Yuka, Shibata, Chiaki, Kanuma, Shinnosuke, Yoshizaki, Akiko, Takizawa, Yuka, Hashimoto, Yuichi
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 2015
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Glutarimide
DESIGN
Biological Activity
Thalidomide
Hydantoin
Succinimide
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Summary:Several derivatives of hydantoin containing glutarimide or succinimide at the 3-position were synthesized. The new hydantoin derivatives had a structure similar to that of thalidomide, and so may possess activity similar to that of thalidomide and/or its analogs, such as effects on cell differentiation and angiogenesis. Some hydantoins showed enhancing effects on all-trans retinoic acid (ATRA)-induced cell differentiation of human leukemia cell line HL-60 and anti-angiogenic activity on human umbilical vein endothelial cells (HUVEC). These new hydantoin derivatives were more effective than thalidomide in cell differentiation-inducing activity on HL-60 and anti-angiogenic activity on HUVEC.
ISSN:0385-5414
1881-0942
DOI:10.3987/COM-15-13184