[Ru(η 6 - p -cymene)(N^O 8-hydroxyquinoline)(PTA)] complexes as rising stars in medicinal chemistry: synthesis, properties, biomolecular interactions, in vitro anti-tumor activity toward human brain carcinomas, and in vivo biodistribution and toxicity in a zebrafish model

• Published in: Dalton transactions : an international journal of inorganic chemistry Vol. 51; no. 21; pp. 8497 - 8509
• Main Authors: P K, Anuja, Roy, Nilmadhab, Das, Utpal, Varddhan, Seshu, Sahoo, Suban K, Paira, Priyankar
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 31.05.2022
• Subjects: Anticancer properties; Astrochemistry; Biocompatibility; Biodistribution; Brain; Brain cancer; Cancer; Chemical synthesis; Electrophoresis; Hydroxyquinoline; Organs; Polymerase chain reaction; Time dependence; Toxicity; Zebrafish
• ISSN: 1477-9226; 1477-9234
• DOI: 10.1039/d2dt00666a

Herein, we have introduced a class of half-sandwich [Ru(η - -cymene)(N^O 8-hydroxyquinoline)(PTA)] complexes for brain cancer therapy. Among all the complexes, [RuL3PTA] and [RuL4PTA] exhibited excellent cytotoxicity profiles against T98G, LN229, and U87MG cancer cells. Notably, the antiproliferative activities of the relevant complexes were also supported by neurosphere, DNA intercalation, agarose gel electrophoresis, and time-dependent ROS detection assay studies. Detailed molecular assays were obtained real-time reverse transcription (RT)-polymerase chain reaction (PCR) experiments. Moreover, the biodistribution of the [RuL4PTA] complex in different organs and the morphological patterns of zebrafish embryos due to toxic effects have been evaluated.