THF-γ2, a thymic hormone, increases immunocompetence and survival in 5-fluorouracil-treated mice bearing MOPC-315 plasmacytoma

The effect of the thymic hormone, THF-γ2, on the immunocompetence of 5-fluorouracil (5-FU)-treated BALB/c mice, bearing MOPC-315 tumor, was examined. Treatment of noninoculated or tumor-bearing mice with THF-γ2 after 5-FU injection, resulted in an increase in the antibody response to sheep red blood...

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Published inCancer Immunology Immunotherapy Vol. 30; no. 2; pp. 119 - 125
Main Authors OPHIR, R, PECHT, M, HALPERIN, D, RASHID, G, BURSTEIN, Y, SHLOMO BEN-EFRAIM, TRAININ, N
Format Journal Article
LanguageEnglish
Published Berlin Springer 01.03.1989
Springer-Verlag
Subjects
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Medical sciences
Original
Pharmacology. Drug treatments
Antineoplastic agent
Therapeutic efficiency
Immunopathology
Drug combination
Rodentia
Malignant hemopathy
Vertebrata
Chemotherapy
Mammalia
Mouse
Animal
Immunocompetence
Plasmacytoma
Thymus hormone
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Summary:The effect of the thymic hormone, THF-γ2, on the immunocompetence of 5-fluorouracil (5-FU)-treated BALB/c mice, bearing MOPC-315 tumor, was examined. Treatment of noninoculated or tumor-bearing mice with THF-γ2 after 5-FU injection, resulted in an increase in the antibody response to sheep red blood cells and in the allogeneic response in spleen cell cultures and had no effect on the concanavalin-A-induced interleukin-2 secretion beyond that caused by 5-FU alone. Treatment with either 5-FU alone or 5-FU and THF-γ2 resulted in restoration to normal values of Lytl- and L3T4-positive populations in tumor-bearing mice. THF-γ2 prolonged the survival time of mice bearing MOPC-315 tumor beyond that observed in mice treated with 5-FU alone.
ISSN:0340-7004
1432-0851
DOI:10.1007/BF01665963