Evaluation of functional MR-urography in complex obstructive uropathy of infants: comparison to the conventional diagnostic algorithm--a pilot study

• Published in: Klinische Padiatrie Vol. 224; no. 5; p. 296
• Main Authors: Furth, C, Genseke, P, Amthauer, H, Neumann, G, Krause, H, Seidensticker, M, Wiemann, D, Rißmann, A, Liehr, U-B, Ruf, J
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2012
• Subjects: Algorithms; Constriction, Pathologic - diagnosis; Constriction, Pathologic - physiopathology; Constriction, Pathologic - surgery; Diagnosis, Differential; Female; Humans; Hydronephrosis - congenital; Hydronephrosis - diagnosis; Hydronephrosis - physiopathology; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Infant; Kidney Function Tests; Magnetic Resonance Imaging - methods; Male; Pilot Projects; Radioisotope Renography; Retrospective Studies; Sensitivity and Specificity; Urinary Tract - abnormalities; Urinary Tract - physiopathology; Urinary Tract - surgery; Urodynamics - physiology; Urography - methods
• ISSN: 1439-3824
• DOI: 10.1055/s-0032-1316295

To analyze the impact of functional magnetic resonance urography (fMRU) on the therapeutic management in infants with complex obstructive uropathy (OU) compared to the conventional diagnostic algorithm [CDA, ultrasound, radioisotope nephrography (RN)]. Retrospective analysis on 10 consecutive infants [female, n=3; male, n=7; age, 10.7 (2-17) months] with OU. Patients were examined according to CDA. If CDA revealed inconclusive results, fMRU was performed additionally. Split kidney function was assessed by RN [single kidney function (SKF)] and fMRU [volumetric differential renal function (vDRF)]. Findings were presented to an interdisciplinary truth-panel in a 2-step decision process (with and without fMRU). Clinical decision was determined. CDA indicated surgical intervention in 8 patients and conservative treatment in 2. Information by fMRU changed treatment strategy in 3 patients and led to the modification of the initially chosen surgical approach in 8 cases. The comparison of SKF and vDRF was not possible in 1 patient, whereas concordance was observed in 7 patients. SKF and vDRF differed >5% in 2 patients. fMRU has potential to improve therapeutic management of OU in infants. If surgical treatment is advised, the morphological information by fMRU has to be emphasized. Regarding kidney function estimation preliminary results are encouraging.