Antioxidant, hypolipidemic and hypoglycemic effect of red wine in wistar rats fed with obesogenic diet

The health benefits resulting from the usual ingestion of red wines have been studied in humans and animals. However, the evaluation of benefits in antioxidant, hypoglycemic and hypolipemic activity concomitant with the use of an obesogenic diet in adult Wistar rats has been little explored. The pre...

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Published inFood bioscience Vol. 47; p. 101671
Main Authors Mucaca, Cornélio, Tavares Filho, José Henrique, Arruda, Luciana Lima, Galvão, André Martins, Bernadete de Sousa Maia, Maria, Maria dos Santos Alves, Eryka, de Souza Franco, Eryvelton, Nascimento, Elizabeth do
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.06.2022
Subjects
Dyslipidemia
Obesity
Rats
Red wine
Westernized diet
Rats
Obesity
Red wine
Dyslipidemia
Westernized diet
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Summary:The health benefits resulting from the usual ingestion of red wines have been studied in humans and animals. However, the evaluation of benefits in antioxidant, hypoglycemic and hypolipemic activity concomitant with the use of an obesogenic diet in adult Wistar rats has been little explored. The present study investigated the use of red wine derived from Northeast Brazil in adult rats fed with an obesogenic diet on antioxidant activity, glucose tolerance, adipose, glycemic and lipemic profile. Sixty 45-day old male Wistar rats formed two groups: standard diet and westernized diet. After changes in body mass and glycemic levels, the animals were subdivided into six subgroups (n = 10 per group) and received water, red wine or hydroalcoholic solution by gavage. The data reveal that the moderate and chronic use of red wine improves the glycemic, lipid and oxidative stress profile, being favorable in preventing the risk of cardiovascular diseases in rats fed with an obesogenic diet. [Display omitted]
ISSN:2212-4292
2212-4306
DOI:10.1016/j.fbio.2022.101671