The impact of nimodipine combined with Ginkgo biloba extract on cognitive function and ADL scores in patients with Parkinson's disease: A retrospective study

• Published in: Medicine (Baltimore) Vol. 103; no. 29; p. e38720
• Main Authors: Zhang, Lianlian, Sun, Hua, Han, Zaigang
• Format: Journal Article
• Language: English
• Published: United States 19.07.2024
• Subjects: Activities of Daily Living; Aged; Cognition - drug effects; Drug Therapy, Combination; Female; Ginkgo biloba; Ginkgo Extract; Humans; Male; Middle Aged; Nimodipine - administration & dosage; Nimodipine - therapeutic use; Parkinson Disease - drug therapy; Parkinson Disease - psychology; Plant Extracts - therapeutic use; Retrospective Studies; Treatment Outcome
• ISSN: 0025-7974; 1536-5964; 1536-5964
• DOI: 10.1097/MD.0000000000038720

This study aims to explore the value of nimodipine combined with Ginkgo biloba extract in improving cognitive function and daily living abilities in patients with Parkinson's disease. Clinical data from 551 patients with Parkinson's disease admitted to the Neurology Department of the Affiliated Hospital of Beihua University from January 2022 to December 2022 were retrospectively collected. Cognitive function and daily living abilities were assessed in patients before treatment, and a reevaluation was conducted after 12 weeks of medication. Patients treated solely with nimodipine were categorized into the monotherapy group, while patients treated with nimodipine combined with Ginkgo biloba extract were included in the combination group. After 1:1 propensity score matching, a total of 83 pairs of patients were matched, and differences in relevant indicators between the 2 groups were compared. The total effective rate of treatment in the combination group was 90.36%, which was higher than the control group at 72.29% (P < .05). However, after treatment, the observation group showed higher Mini-Mental State Examination and activities of daily living scores compared to the control group (P < .05). The combined treatment of nimodipine and Ginkgo biloba extract in patients with Parkinson's disease has a significant effect and can effectively improve cognitive function and enhance daily living abilities.