Startle Seizures and Diffuse Leukoencephalopathy After Resolution of Herpes Simplex Virus 1 Encephalitis in a Child

We describe a unique clinical presentation of a child after the acute phase of herpes simplex virus 1 (HSV1) encephalitis. A 17-month-old boy first presented with HSV1 encephalitis and was promptly treated with antiviral medication. Seven months later, he was re-admitted for startle seizures. Magnet...

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Bibliographic Details
Published inChild neurology open Vol. 9; p. 2329048X221083761
Main Authors Ng, Andy Cheuk-Him, Kassiri, Janani, Goez, Helly R., Morneau-Jacob, Francois, Mailo, Janette
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2022
Sage Publications Ltd
Subjects
Brain injury
Case Report
Encephalitis
Herpes simplex
Leukoencephalopathy
Magnetic resonance imaging
Neuroimaging
Seizures
Substantia alba
leukoencephalopathy
herpes simplex virus 1
reflex seizures
encephalitis
startle seizures
epileptic spasms
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Summary:We describe a unique clinical presentation of a child after the acute phase of herpes simplex virus 1 (HSV1) encephalitis. A 17-month-old boy first presented with HSV1 encephalitis and was promptly treated with antiviral medication. Seven months later, he was re-admitted for startle seizures. Magnetic Resonance Imaging of the brain showed diffuse confluent leukoencephalopathy. This constellation of symptoms has not been previously reported in HSV1 encephalitis. In conclusion, we showed that brain injury due to HSV1 encephalitis can be associated with the development of startle seizures and diffuse white matter injury in the post-acute phase.
ISSN:2329-048X
2329-048X
DOI:10.1177/2329048X221083761