Comparison of Osteogenesis Between Two Kinds of Stem Cells from Goat Combined Calcium Phosphate Cement in Tissue Engineering

To explore the possible mechanism of osteogenesis for deciduous teeth stem cells （DTSCs） in vivo/ vitro, stem cells from goat deciduous teeth （SGDs） were firstly isolated, induced and transplanted into immunocompromised mice. The SGDs＇s mineralization pattern and osteogenesis were compared with bone...

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Published inShanghai jiao tong da xue xue bao Vol. 16; no. 5; pp. 628 - 635
Main Author 赵伟 陆家瑜 郝永明 张秀丽 瞿晓辉 华丽 曹春花 邹德荣
Format Journal Article
LanguageEnglish
Published Heidelberg Shanghai Jiaotong University Press 01.10.2011
Subjects
Architecture
Computer Science
Electrical Engineering
Engineering
Life Sciences
Materials Science
mineralization
tissue engineering
osteogenesis
bone marrow mesenchymal stem cells (BMMSCs)
R 782.1
stem cells from goat deciduous teeth (SGDs)
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Summary:To explore the possible mechanism of osteogenesis for deciduous teeth stem cells （DTSCs） in vivo/ vitro, stem cells from goat deciduous teeth （SGDs） were firstly isolated, induced and transplanted into immunocompromised mice. The SGDs＇s mineralization pattern and osteogenesis were compared with bone marrow messenchymal stem cells （BMMSCs） from goats. SGDs have similar osteogenic differentiation pattern in vitro and bone-like tissue formation mechanism in vivo to BMMSCs; moreover SGDs have stronger alkaline phosphatase （ALP） gene expression and osteopontin （OPN） gene expression levels than BMMSCs; also SGDs can form more bone-like tissues than BMMSCs when cell-scaffold compounds are transplanted into immunocompromised mice. This pre-clinical study in a large-animal model confirms that DTSCs may be an appropriate source of stem cells in repairing bone defects with tissue engineering.
Bibliography:stem cells from goat deciduous teeth （SGDs）, mineralization, osteogenesis, bone marrow mesenchymal stem cells （BMMSCs）, tissue engineering
31-1943/U
To explore the possible mechanism of osteogenesis for deciduous teeth stem cells （DTSCs） in vivo/ vitro, stem cells from goat deciduous teeth （SGDs） were firstly isolated, induced and transplanted into immunocompromised mice. The SGDs＇s mineralization pattern and osteogenesis were compared with bone marrow messenchymal stem cells （BMMSCs） from goats. SGDs have similar osteogenic differentiation pattern in vitro and bone-like tissue formation mechanism in vivo to BMMSCs; moreover SGDs have stronger alkaline phosphatase （ALP） gene expression and osteopontin （OPN） gene expression levels than BMMSCs; also SGDs can form more bone-like tissues than BMMSCs when cell-scaffold compounds are transplanted into immunocompromised mice. This pre-clinical study in a large-animal model confirms that DTSCs may be an appropriate source of stem cells in repairing bone defects with tissue engineering.
ISSN:1007-1172
1995-8188
DOI:10.1007/s12204-011-1200-x